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dc.contributor.authorDINIZ, W. J. da S.eng
dc.contributor.authorCOUTINHO, L. L.eng
dc.contributor.authorTIZIOTO, P. C.eng
dc.contributor.authorCESAR, A. S. M.eng
dc.contributor.authorGROMBONI, C. F.eng
dc.contributor.authorNOGUEIRA, A. R. de A.eng
dc.contributor.authorOLIVEIRA, P. S. N. deeng
dc.contributor.authorSOUZA, M. M. deeng
dc.contributor.authorREGITANO, L. C. de A.eng
dc.date.accessioned2019-04-02T00:32:02Z-
dc.date.available2019-04-02T00:32:02Z-
dc.date.created2016-10-20
dc.date.issued2016
dc.identifier.citationPlos One, aug. 2016.eng
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1055127-
dc.descriptionIron (Fe) is an essential mineral for metabolism and plays a central role in a range of biochemical processes. Therefore, this study aimed to identify differentially expressed (DE) genes and metabolic pathways in Longissimus dorsi (LD) muscle from cattle with divergent iron content, as well as to investigate the likely role of these DE genes in biological processes underlying beef quality parameters. Samples for RNA extraction for sequencing and iron, copper, manganese, and zinc determination were collected from LD muscles at slaughter. Eight Nelore steers, with extreme genomic estimated breeding values for iron content (Fe-GEBV), were selected from a reference population of 373 animals. From the 49 annotated DE genes (FDR<0.05) found between the two groups, 18 were upregulated and 31 down-regulated for the animals in the low Fe-GEBV group. The functional enrichment analyses identified several biological processes, such as lipid transport and metabolism, and cell growth. Lipid metabolism was the main pathway observed in the analysis of metabolic and canonical signaling pathways for the genes identified as DE, including the genes FASN, FABP4, and THRSP, which are functional candidates for beef quality, suggesting reduced lipogenic activities with lower iron content. Our results indicate metabolic pathways that are partially influenced by iron, contributing to a better understanding of its participation in skeletal muscle physiology.eng
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectFisiologia esquelético musculareng
dc.subjectMetabolismo lipídicoeng
dc.titleIron content affects lipogenic gene expression in the muscle of nelore beef cattle.eng
dc.typeArtigo de periódicoeng
dc.date.updated2019-04-02T00:32:02Z
dc.subject.thesagroGado Neloreeng
dc.subject.thesagroFerroeng
dc.subject.nalthesaurusNelloreeng
riaa.ainfo.id1055127eng
riaa.ainfo.lastupdate2019-04-01
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0161160eng
dc.contributor.institutionWELLISON JARLES DA SILVA DINIZ, UFSCAR; LUIZ LEHMANN COUTINHO, USP; POLYANA CRISTINE TIZIOTO, FAPESP; ALINE SILVA MELLO CESAR, USP/ESALQ; CAIO FERNANDO GROMBONI, UFBA; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; PRISCILA SILVA NEUBERN DE OLIVEIRA, FAPESP; MARCELA MARIA DE SOUZA, UFSCAR; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.eng
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