Title:	Bioactivity and action mechanism of green propolis against Pythium aphanidermatum.
Authors:	PAZIN, W. M. SANTOS, S. N. QUEIROZ, S. C. do N. de BAGATOLLI, L. A. SOARES, A. E. E. MELO, I. S. de ITO, A. S.
Affiliation:	WALLANCE MOREIRA PAZIN, FFCLRP-USP; SUIKINAI NOBRE SANTOS; SONIA CLAUDIA DO N DE QUEIROZ, CNPMA; LUIS ALBERTO BAGATOLLI, Instituto de Investigaciones Medicas Mercedes y Martín Ferreyra/; ADEMILSON ESPENCER EGEA SOARES, FMRP-USP; ITAMAR SOARES DE MELO, CNPMA; AMANDO SIUITI ITO, FFCLRP-USP.
Date Issued:	2019
Citation:	Anais da Academia Brasileira de Ciências, v. 91, n. 2, 2019. Article e20180598.
Description:	Abstract: We have established how natural compounds from green propolis collected by the species Apis mellifera act against the growth of Pythium aphanidermatum. On the basis of mass spectrometry (Q-ToF MS), we determined that Artepillin C, the major constituent of green propolis, underlies the effect and displays activity against P. aphanidermatum at a minimal inhibitory concentration of 750 ?g.ml-1. Biophysical studies based on model membranes showed that this inhibitory effect may be linked with a membrane-related phenomenon: Artepillin C increases the permeability of membranes with relatively high fluidity in their lateral structure, a feature that is in line with the lipid composition reported for the cytoplasmic membrane of P. aphanidermatum. Therefore, the present study supports the use of the effective and inexpensive green propolis to control the impact of the dangerous phytopathogen P. aphanidermatumon agriculture.
Thesagro:	Própolis Pythium aphanidermatum Controle biológico Doença de Planta
NAL Thesaurus:	Biological control Pythium Plant diseases and disorders
Keywords:	Green propolis Artepillin C Model membranes
DOI:	http://dx.doi.org/10.1590/0001-3765201920180598
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPMA)