Título:	Muscle transcriptome analysis reveals genes and metabolic pathways related to mineral concentration in Bos indicus.
Autoria:	AFONSO, J. COUTINHO, L. L. TIZIOTO, P. C. DINIZ, W. J. da S. LIMA, A. O. de ROCHA, M. I. P. BUSS, C, E. ANDRADE, B. G. N. A. PIAYA. O. SILVA, J. V. LINS, L. A. GROMBONI, C. F. NOGUEIRA, A. R. de A. FORTES, M. R. S. MOURÃO, G. B. REGITANO, L. C. de A.
Afiliação:	Juliana Afonso, UFSCAR; Luiz Lehmann Coutinho, USP; Polyana Cristine Tizioto; Wellison Jarles da Silva Diniz, UFSCAR; Andressa Oliveira de Lima; Marina Ibelli Pereira Rocha, UFSCAR; Carlos Eduardo Buss, UFSCAR; Bruno Gabriel nascimento Andrade; Otávio Piaya, UFSCAR; Juliana Virginio da Silva, USP; Laura Albuquerque Lins, USP; Caio Fernando Gromboni, Instituto Federal de Educação, Ciência e Tecnologia da Bahia; ANA RITA DE ARAUJO NOGUEIRA, CPPSE; Marina Rufino Salinas Fortes, University of Queensland; Gerson Barreto Mourão, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Ano de publicação:	2019
Referência:	Scientific Reports, v. 9, n. 12715, 2019.
Conteúdo:	Mineral content affects the biological processes underlying beef quality. Muscle mineral concentration depends not only on intake-outtake balance and muscle type, but also on age, environment, breed, and genetic factors. To unveil the genetic factors involved in muscle mineral concentration, we applied a pairwise diferential gene expression analysis in groups of Nelore steers genetically divergent for nine diferent mineral concentrations. Here, based on signifcant expression diferences between contrasting groups, we presented candidate genes for the genetic regulation of mineral concentration in muscle. Functional enrichment and protein-protein interaction network analyses were carried out to search for gene regulatory processes concerning each mineral. The core genetic regulation for all minerals studied, except Zn, seems to rest on interactions between components of the extracellular matrix. Regulation of adipogenesis-related pathways was also signifcant in our results. Antagonistic patterns of gene expression for fatty acid metabolism-related genes may explain the Cu and Zn antagonistic efect on fatty acid accumulation. Our results shed light on the role of these minerals on cell function
Thesagro:	Gado Nelore Gado de Corte Melhoramento Genético Animal
NAL Thesaurus:	Beef quality Beef cattle Animal breeding
Palavras-chave:	Muscle type Mineral concentrations Nelore Qualidade da carne
Digital Object Identifier:	https://doi.org/10.1038/s41598-019-49089-x
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CPPSE)