Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563
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dc.contributor.authorBRUNES, L. C.
dc.contributor.authorBALDI, F.
dc.contributor.authorLOPES, F. B.
dc.contributor.authorLOBO, R. B.
dc.contributor.authorESPIGOLAN, R.
dc.contributor.authorCOSTA, M. F. O. e
dc.contributor.authorSTAFUZZA, N. B.
dc.contributor.authorMAGNABOSCO, C. de U.
dc.date.accessioned2021-11-25T15:00:25Z-
dc.date.available2021-11-25T15:00:25Z-
dc.date.created2021-11-25
dc.date.issued2021
dc.identifier.citationJournal of Animal Breeding and Genetics, v. 138, p. 23-44, 2021.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1136563-
dc.descriptionAbstract The aim was to conduct a weighted single-step genome-wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein-coding genes were identified within the genomic regions that explain more than 0.5% of the ad- ditive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient ab- sorption. Enrichment analysis revealed functional pathways (p-value&#57375;<&#57375;.05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/ Int-1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste trans- duction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE- related traits.
dc.language.isoeng
dc.rightsopenAccesseng
dc.subjectRação residual
dc.subjectEtapa única ponderada
dc.titleWeighted single-step genome-wide association study and pathway analyses for feed efficiency traits in Nellore cattle.
dc.typeArtigo de periódico
dc.subject.thesagroGado
dc.subject.thesagroGanho de Peso
riaa.ainfo.id1136563
riaa.ainfo.lastupdate2021-11-25
dc.contributor.institutionLUDMILLA C. BRUNES; FERNANDO BALDI; FERNANDO B. LOPES; RAYSILDO B. LÔBO; RAFAEL ESPIGOLAN; MARCOS FERNANDO OLIVEIRA E COSTA, CNPAF; NEDENIA B. STAFUZZA; CLAUDIO DE ULHOA MAGNABOSCO, CPAC.
Aparece nas coleções:Artigo em periódico indexado (CPAC)

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