Título:	Characterization of gels and films produced from pinhão seed coat nanocellulose as a potential use for wound healing dressings and screening of Its compounds towards antitumour effects.
Autoria:	LIMA, T. A. de M. de LIMA, G. G. de CHEE, B. S. HENN, J. G. CORTESE, Y. J. MATOS, M. HELM, C. V. MAGALHAES, W. L. E. NUGENT, M. J. D.
Afiliação:	TIELIDY A. DE M. DE LIMA, Technological University of the Shannon; GABRIEL GOETTEN DE LIMA, Technological University of the Shannon; BOR SHIN CHEE, Technological University of the Shannon; JEFERSON G. HENN, Technological University of the Shannon; YVONNE J. CORTESE, Technological University of the Shannon; MAILSON MATOS, Bolsista da Embrapa Florestas; CRISTIANE VIEIRA HELM, CNPF; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF; MICHAEL J. D. NUGENT, Technological University of the Shannon.
Ano de publicação:	2022
Referência:	Polymers, v. 14, 2776, 2022.
Conteúdo:	ABSTRACT. The reuse of agro-industrial waste assumes great importance today. Pinhão is the seed of Araucaria angustifolia, which is native to the mountains of southern Brazil, Paraguay, and Argentina. The coat is a by-product of this seed and is rich in phenolic compounds. The present study aimed to use the residue as a precursor material for the production of nanocellulose through the mechanical defibrillation process and perform the characterization of the films and the gel to investigate the effect on the physical and regenerative properties when incorporated with polyvinyl alcohol (PVA). The modulus of elasticity was higher when the MFC of pinhão was added to the PVA. Film and gel had their cytotoxicity tested by MTT assay using 3T3 fibroblast and Schwann cancer cells, and a migration assay was also performed using the scratch test on HaCat keratinocyte cells. For the scratch test, film and gel samples with low concentration presented a complete scratch closure in 72 h. Molecular docking was performed and quercetin had the ideal interaction score values, so it was used with the PACAP protein which presented a slightly moderate interaction with the protein synthesis of Schwann cells, presenting compactness of the compound after 14 ns.
Thesagro:	Cicatrização
NAL Thesaurus:	Antioxidants
Palavras-chave:	Antioxidantes Pinhão seed coat Nanocellulose Nanocelulose Wound healing
Digital Object Identifier:	https://doi.org/10.3390/polym14142776
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPF)