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dc.contributor.authorCARNEIRO, C. V. G. C.
dc.contributor.authorSERRA, L. A.
dc.contributor.authorPACHECO, T. F.
dc.contributor.authorFERREIRA, L. M. M.
dc.contributor.authorDUARTE, L. T.
dc.contributor.authorFREITAS, M. N. de M.
dc.contributor.authorTRICHEZ, D.
dc.contributor.authorALMEIDA, J. R. M. de
dc.date.accessioned2022-11-23T12:01:20Z-
dc.date.available2022-11-23T12:01:20Z-
dc.date.created2022-11-23
dc.date.issued2022
dc.identifier.citationFermentation, v. 8, n. 575, p. 2-37, 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1148607-
dc.descriptionThe need for a more sustainable society has prompted the development of bio-based processes to produce fuels, chemicals, and materials in substitution for fossil-based ones. In this context, microorganisms have been employed to convert renewable carbon sources into various products. The methylotrophic yeast Komagataella phaffii has been extensively used in the production of heterologous proteins. More recently, it has been explored as a host organism to produce various chemicals through new metabolic engineering and synthetic biology tools. This review first summarizes Komagataella taxonomy and diversity and then highlights the recent approaches in cell engineering to produce renewable chemicals and proteins. Finally, strategies to optimize and develop new fermentative processes using K. phaffii as a cell factory are presented and discussed. The yeast K. phaffii shows an outstanding performance for renewable chemicals and protein production due to its ability to metabolize different carbon sources and the availability of engineering tools. Indeed, it has been employed in producing alcohols, carboxylic acids, proteins, and other compounds using different carbon sources, including glycerol, glucose, xylose, methanol, and even CO2.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectKomagataella phaffii
dc.titleAdvances in Komagataella phaffii Engineering for the Production of Renewable Chemicals and Proteins
dc.typeArtigo de periódico
dc.subject.thesagroBiologia Vegetal
dc.subject.nalthesaurusPichia pastoris
dc.subject.nalthesaurusBioengineering
riaa.ainfo.id1148607
riaa.ainfo.lastupdate2022-11-23
dc.identifier.doihttps://doi.org/10.3390/fermentation8110575
dc.contributor.institutionCLARA VIDA GALRÃO CORRÊA CARNEIRO, UNB/CNPAE; LUANA ASSIS SERRA, UNB/CNPAE; THALYTA FRAGA PACHECO, CNPAE; LETÍCIA MARIA MALLMANN FERREIRA, UNB/CNPAE; LIVIA TEIXEIRA DUARTE BRANDAO, CNPAE; MARIANA NOGUEIRA DE MOURA FREITAS, UNB/CNPAE; DÉBORA TRICHEZ, UNB/CNPAE; JOAO RICARDO MOREIRA DE ALMEIDA, CNPAE.
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