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dc.contributor.authorAFONSO, J.
dc.contributor.authorSHIM, W. J.
dc.contributor.authorBODEN, M.
dc.contributor.authorFORTES, M. R. S.
dc.contributor.authorDINIZ, W. J. da S.
dc.contributor.authorLIMA, A. O. de
dc.contributor.authorROCHA, M. I. P.
dc.contributor.authorCARDOSO, T. F.
dc.contributor.authorBRUSCADIN, J. J.
dc.contributor.authorGROMBONI, C. F.
dc.contributor.authorNOGUEIRA, A. R. A.
dc.contributor.authorMOURÃO, G. B.
dc.contributor.authorZERLOTINI NETO, A.
dc.contributor.authorCOUTINHO, L. L.
dc.contributor.authorREGITANO, L. C. de A.
dc.date.accessioned2023-02-09T17:01:38Z-
dc.date.available2023-02-09T17:01:38Z-
dc.date.created2023-02-09
dc.date.issued2023
dc.identifier.citationBiochemistry and Biophysics Reports, v. 33, 101420, Mar. 2023.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1151623-
dc.descriptionAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectH3K27me3
dc.subjectExpressão gênica
dc.subjectGene repression
dc.subjectEpigenetic regulation
dc.titleRepressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle.
dc.typeArtigo de periódico
dc.subject.thesagroGado de Corte
dc.subject.thesagroGado Nelore
dc.subject.thesagroBos Indicus
dc.subject.thesagroMineral
dc.subject.nalthesaurusEpigenetics
dc.subject.nalthesaurusGene expression
dc.subject.nalthesaurusMinerals
riaa.ainfo.id1151623
riaa.ainfo.lastupdate2023-02-09
dc.identifier.doihttps://doi.org/10.1016/j.bbrep.2023.101420
dc.contributor.institutionJULIANA AFONSO; WOO JUN SHIM, THE UNIVERSITY OF QUEENSLAND; MIKAEL BODEN, THE UNIVERSITY OF QUEENSLAND; MARINA RUFINO SALINAS FORTES, THE UNIVERSITY OF QUEENSLAND; WELLISON JARLES DA SILVA DINIZ, AUBURN UNIVERSITY; ANDRESSA OLIVEIRA DE LIMA, UNIVERSITY OF WASHINGTON; MARINA IBELLI PEREIRA ROCHA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; TAINÃ FIGUEIREDO CARDOSO; JENNIFER JESSICA BRUSCADIN, UNIVERSIDADE FEDERAL DE SÃO CARLOS; CAIO FERNANDO GROMBONI, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DA BAHIA; ANA RITA ARAUJO NOGUEIRA; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
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