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dc.contributor.authorSABINO, L. B. de S.
dc.contributor.authorCOPES, F.
dc.contributor.authorSAULAIS, S.
dc.contributor.authorBRITO, E. S. de
dc.contributor.authorSILVA JÚNIOR, I. J. da
dc.contributor.authorLE, T. C.
dc.contributor.authorMATEESCU, M. A.
dc.contributor.authorMANTOVANI, D.
dc.date.accessioned2023-05-10T05:55:51Z-
dc.date.available2023-05-10T05:55:51Z-
dc.date.created2023-05-09
dc.date.issued2022
dc.identifier.citationMolecules, v. 27, n. 21, 7271, p. 1-19, 2022.
dc.identifier.issn1420-3049
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1153621-
dc.descriptionAnthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectCarboxymethyl starch
dc.subjectBioactive agent delivery
dc.subjectMonolithic tablets
dc.subjectJamelão
dc.subjectAgente bioativo
dc.subjectAntioxidantes
dc.subjectAntitumoral
dc.subjectAntiaterosclerótica
dc.subjectAntioxidant activities
dc.subjectAntiinflammatory
dc.subjectAntiatherosclerotic activities
dc.titleAnthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery.
dc.typeArtigo de periódico
dc.subject.thesagroFruto
dc.subject.thesagroAntiinflamatório
dc.subject.nalthesaurusAnthocyanins
dc.subject.nalthesaurusSyzygium cumini
dc.subject.nalthesaurusFruit compositioneng
riaa.ainfo.id1153621
riaa.ainfo.lastupdate2023-05-10
dc.identifier.doihttps://doi.org/10.3390/molecules27217271
dc.contributor.institutionLUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University.
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