Title:	New derivatives of dillapiole have ovicidal, larvicidal and adulticidal effect on Aedes (Stegomyia) aegypti (Diptera: Culicidae).
Authors:	SILVA, J. S. da PINTO, A. C. da S. MEIRELES, S. da F. MORAIS, S. A. CRUZ, D. L. V. CHAVES, F. C. M. SOUSA, J. M. de C. RAFAEL, M. S.
Affiliation:	JUNIELSON SOARES DA SILVA, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; ANA CRISTINA DA SILVA PINTO, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; SABRINA DA FONSECA MEIRELES, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; SIRLEI ANTUNES MORAIS, BIOVECTORS - STARTUP DE DESENVOLVIMENTO DE PRODUTOS CONTRA MOSQUITOS VETORES; DANIEL LUÍS VIANA CRUZ, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA; FRANCISCO CELIO MAIA CHAVES, CPAA; JOÃO MARCELO DE CASTRO SOUSA, UNIVERSIDADE FEDERAL DO PIAUÍ; MÍRIAM SILVA RAFAEL, INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA.
Date Issued:	2024
Citation:	Revista Brasileira de Entomologia, v. 68, n. 4, e20240010, 2024.
Description:	The new molecules piperidyl dillapiole and propyl ether dillapiole were evaluated in Aedes aegypti as an alternative for the control of populations of this mosquito. A total of 1,690 samples, comprising 780 eggs, 780 larvae and 130 adults, were treated with both substances for 4 h, 24 h and 90 min, respectively. The dillapiole (80 µg/mL), temephos (0.012 µg/mL) as positive control, and the negative control (water + DMSO 0.05%). The 50% lethal concentrations (LC50) of propyl ether dillapiole and piperidyl dillapiole in eggs were 18.07 and 49.97 µg/mL and, in larvae, the LC50 of these substances were 29.15 and 72.93 µg/mL, which caused darkening of the cuticle and displacement of the head. In the adults, the LC50 of the two substances after 90 min was 148.25 and 263.26 µg/mL, respectively. The insertion of the propyl and piperidine radicals into the dillapiole molecule resulted in the substances propyl ether dillapiole and piperidyl dillapiole, both of which had a toxic effect on Ae. aegypti. However, propyl ether dillapiole, which has propylene in its side chain, showed greater ovicidal, larvicidal and adulticidal activity when compared to piperidyl dillapiole. These results are promising as an alternative form of control of Ae. aegypti, which is the primary vector of human arboviruses.
NAL Thesaurus:	Vector control Piper aduncum Toxicity
Keywords:	Piperidyl Propyl Semi-synthetics
DOI:	https://doi.org/10.1590/1806-9665-RBENT-2024-0010
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPAA)