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dc.contributor.authorNICOLÁS, M. F.pt_BR
dc.contributor.authorBARCELLOS, F. G.pt_BR
dc.contributor.authorHESS, P. N.pt_BR
dc.contributor.authorHUNGRIA, M.pt_BR
dc.date.accessioned2014-01-13T22:20:54Z-
dc.date.available2014-01-13T22:20:54Z-
dc.date.created2008-03-03pt_BR
dc.date.issued2007pt_BR
dc.identifier.citationGenetics and Molecular Biology, Ribeirão Preto, v. 30, n. 1, p. 202-211, 2007. Suplemento.pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/467160pt_BR
dc.descriptionABC transporters represent one of the largest superfamilies of active membrane transport proteins (MTPs) with a highly conserved ATPase domain that binds and hydrolyzes ATP, supplying energy for the uptake of a variety of nutrients and for the extrusion of drugs and metabolic wastes. The complete genomes of a non-pathogenic (J) and pathogenic (7448) strain of Mycoplasma hyopneumoniae, as well as of a pathogenic (53) strain of Mycoplasma synoviaehave been recently sequenced. A detailed study revealed a high percentage of CDSs encoding MTPs in M. hyopneumoniaestrains J (13.4%), 7448 (13.8%), and in M. synoviae53 (11.2%), and the ABC systems represented from 85.0 to 88.6% of those CDSs. Uptake systems are mainly involved in cell nutrition and some might be associated with virulence. Exporter systems include both drug and multidrug resistant systems (MDR), which may represent mechanisms of resistance to toxic molecules. No relation was found between the phylogeny of the ATPase domains and the lifestyle or pathogenicity of Mycoplasma, but several proteins, potentially useful as targets for the control of infections, were identified.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectTransportadores ABCpt_BR
dc.titleABC transporters in Mycoplasma hyopneumoniae and Mycoplasma synoviae: insights into evolution and pathogenicity.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2014-01-13T22:20:54Zpt_BR
riaa.ainfo.id467160pt_BR
riaa.ainfo.lastupdate2014-01-13pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S1415-47572007000200006pt_BR
dc.contributor.institutionMARISA FABIANA NICOLÁS, Laboratório Nacional de Computação Científica; FERNANDO GOMES BARCELLOS; PABLO NEHAB HESS, Laboratório Nacional de Computação Científica; MARIANGELA HUNGRIA DA CUNHA, CNPSO.pt_BR
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