Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/572633
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dc.contributor.authorGRISOLIA, A. B.
dc.contributor.authorD´ANGELO, G. T.
dc.contributor.authorPORTO NETO, L. R.
dc.contributor.authorSIQUEIRA, F.
dc.contributor.authorGARCIA, J. F.
dc.date.accessioned2018-01-29T23:35:05Z-
dc.date.available2018-01-29T23:35:05Z-
dc.date.created2009-10-20
dc.date.issued2009
dc.identifier.citationGenetics and Molecular Research, Ribeirão Preto, v. 8, n. 3, p. 822-830, 2009.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/572633-
dc.descriptionThe myostatin gene, also known as GDF8 (growth differentiation factor 8), is located on bovine chromosome 2 (BTA2); it has three exons and two introns. Myostatin is specifically expressed during embryonic development and in adult skeletal muscle, functioning as a negative regulatory protein. Several cattle breeds (Piedmontese, Belgian Blue and Blond?Aquitaine, and others) show polymorphisms in this gene; these polymorphisms are directly related to the double muscling phenotype. We looked for polymorphisms in the Nellore cattle myostatin gene and compared them with those known for taurine breeds. Seven regions, covering the three exons of this gene, were amplified by polymerase chain reaction and sequenced, including the untranslated region. DNA from 30 adult Nellore animals was collected; DNA sequencing revealed three, seven and four polymorphisms in exons 1, 2 and 3, respectively. We found previously reported polymorphisms, as well as several new ones; for instance, 37 polymorphisms were found in the untranslated region segment, and in introns 1 and 2 there were one and three polymorphisms, respectively. The high degree of allelic heterogeneity in the myostatin gene could be related to its high mutation rate; it also could be the result of a long history of artificial selection for meat production, which has probably favored such modifications and maintained them in cattle populations. These polymorphisms identified in Nellore cattle could be useful for breeding programs.
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectDNA sequencingpt_BR
dc.subjectBovino de Cortept_BR
dc.subjectNelorept_BR
dc.titleMyostatin (GDF8) single nucleotide polymorphisms in Nellore cattle.
dc.typeArtigo de periódico
dc.date.updated2018-01-29T23:35:05Zpt_BR
dc.subject.thesagroMelhoramento genético animal
dc.subject.thesagroDNA
dc.subject.thesagroCarne
dc.subject.nalthesaurusAnimal breeding
dc.subject.nalthesaurusDouble muscling
dc.subject.nalthesaurusNucleotides
riaa.ainfo.id572633
riaa.ainfo.lastupdate2018-01-29
dc.contributor.institutionA. B. GRISOLIA, UNIVERSIDADE ESTADUAL PAULISTA/ UFGD; G. T. D´ANGELO, UNIVERSIDADE ESTADUAL PAULISTA; L. R. PORTO NETO, UNIVERSIDADE ESTADUAL PAULISTA; FABIANE SIQUEIRA, CNPGC; J. F. GARCIA, UNIVERSIDADE ESTADUAL PAULISTA.
Aparece nas coleções:Artigo em periódico indexado (CNPGC)

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