Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/901961
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dc.contributor.authorSILVA, C. A. dapt_BR
dc.contributor.authorOBA, E. T.pt_BR
dc.contributor.authorRAMSDORF, W. A.pt_BR
dc.contributor.authorMAGALHÃES, V. F.pt_BR
dc.contributor.authorCESTARI, M. M.pt_BR
dc.contributor.authorRIBEIRO, C. A. O.pt_BR
dc.contributor.authorASSIS, H. C. S. dept_BR
dc.date.accessioned2011-09-30T11:11:11Zpt_BR
dc.date.accessioned2011-09-30T11:11:11Zpt_BR
dc.date.available2011-09-30T11:11:11Zpt_BR
dc.date.available2011-09-30T11:11:11Zpt_BR
dc.date.created2011-09-30pt_BR
dc.date.issued2011pt_BR
dc.identifier.citationToxicon, Oxford, v. 57, n. 1, p. 141-147, jan. 2011.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/901961pt_BR
dc.descriptionCyanobacterial waterblooms, such as the saxitoxin (STX) producer Cylindrospermopsis raciborskii, have been a worldwide concern in environmental health. However, the bioaccumulation of this neurotoxin in the trophic chain is not completely known. The aim of the present work was to evaluate STX bioaccumulation through chemical analyses and the toxic and trophic effects using biomarkers in the tropical freshwater fish Hoplias malabaricus. They were fed once every five days with Astyanax sp. before being subjected to intraperitoneal inoculation with STX extract (0.08 mg/100 g) obtained by lysis of toxic C. raciborskii strain (T3). After 20 days the brain was collected for acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione (GSH), lipoperoxidation (LPO), protein carbonylation (PCO), and comet assay analysis. The muscle was collected for STX chemical analysis. The activities of SOD and concentrations of PCO and LPO increased. The CAT, GST, and GPx activities decreased. Genotoxicity was observed in the experimental group. STX was not detected in muscle samples. Thus, an oxidative stress was observed in the brain, leading to the damage of lipids, proteins, and DNA. The mechanism of action of the neurotoxin in this subchronic exposure suggests an apoptotic cellular process.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleFirst report about saxitoxins in freshwater fish Hoplias malabaricus through trophic exposure.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-05-29T11:11:11Zpt_BR
dc.subject.thesagroPeixe de água docept_BR
dc.subject.thesagroTraírapt_BR
dc.subject.thesagroToxinapt_BR
riaa.ainfo.id901961pt_BR
riaa.ainfo.lastupdate2017-05-29pt_BR
dc.contributor.institutionELIANE TIE OBA YOSHIOKA, CPAF-AP.pt_BR
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