Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/902781
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dc.contributor.authorRODRIGUES, I. A.pt_BR
dc.contributor.authorALVIANO, D. S.pt_BR
dc.contributor.authorGOMES, M. T.pt_BR
dc.contributor.authorSILVA, D. O.pt_BR
dc.contributor.authorANTONIASSI, R.pt_BR
dc.contributor.authorSILVA, A. J. R.pt_BR
dc.contributor.authorBIZZO, H. R.pt_BR
dc.contributor.authorALVIANO, C. S.pt_BR
dc.contributor.authorVERMELHO, A. B.pt_BR
dc.contributor.authorROSA, M. do S. S.pt_BR
dc.date.accessioned2011-10-10T11:11:11Zpt_BR
dc.date.accessioned2011-10-10T11:11:11Zpt_BR
dc.date.available2011-10-10T11:11:11Zpt_BR
dc.date.available2011-10-10T11:11:11Zpt_BR
dc.date.created2011-10-10pt_BR
dc.date.issued2011pt_BR
dc.identifier.citationJournal of Medicinal Plants Research, v. 5, n. 16, p. 3781-3790, Aug. 2011.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/902781pt_BR
dc.descriptionLeishmania amazonensis is one of the major etiological agents of diffuse cutaneous leishmaniasis, which is frequently unresponsive to all known treatments. Syagrus coronata (Arecaceae) is a palm tree with industrial applications used in local medicine by the Brazilian ?caatinga? communities. This work evaluates the in vitro leishmanicidal activity of S. coronata on L. amazonensis. Promastigote forms of L. amazonensis were treated with different concentrations of the aqueous extract from S. coronata. In addition, we evaluated the effect of the aqueous extract on infection of mouse peritoneal macrophages and nitric oxide production. The minimal inhibitory concentration (MIC) of the aqueous extract of S. coronata was 8.3 µg/ml. Morphological changes in L. amazonensis promastigotes treated with 50 µg/ml of the aqueous extract were observed by light microscopy. Pretreatment of mouse peritoneal macrophages with 33 µg/ml of S. coronata aqueous extract reduced the association index between macrophages and L. amazonensis by 70.4%, with a concomitant increase of 158.3% in nitric oxide production by the infected macrophages. In addition, the aqueous extract exhibited no cytotoxic effect on mammalian cells and elicited no allergic reactions in vivo, indicating good prospects for the development of new drugs of herbal origins to treat leishmaniasis.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleIn vitro anti-Leishmania amazonensis activity of the polymeric procyanidin-rich aqueous extract from Syagrus coronata.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2011-10-10T11:11:11Zpt_BR
dc.subject.thesagroSyagrus Coronatapt_BR
dc.subject.nalthesaurusSyagruspt_BR
dc.subject.nalthesaurusArecaceaept_BR
dc.subject.nalthesaurusNitric oxidept_BR
dc.subject.nalthesaurusLeishmania amazonensispt_BR
dc.subject.nalthesaurusLeishmaniapt_BR
riaa.ainfo.id902781pt_BR
riaa.ainfo.lastupdate2011-10-10pt_BR
dc.contributor.institutionIGOR A. RODRIGUES, UFRJ; DANIELA S. ALVIANO, UFRJ; MARTA T. GOMES, UFRJ; DAVI O. SILVA, UFRJ; ROSEMAR ANTONIASSI, CTAA; ANTONIO JORGE R. SILVA, UFRJ; HUMBERTO RIBEIRO BIZZO, CTAA; CELUTA S. ALVIANO, UFRJ; ALANE B. VERMELHO, UFRJ; MARIA DO SOCORRO S. ROSA, UFRJ.pt_BR
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