Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/905555
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dc.contributor.authorFASSINI, P. G.pt_BR
dc.contributor.authorNODA, R. W.pt_BR
dc.contributor.authorFERREIRA, E. S.pt_BR
dc.contributor.authorSILVA, M. A.pt_BR
dc.contributor.authorNEVES, V. A.pt_BR
dc.contributor.authorDEMONTE, A.pt_BR
dc.date.accessioned2011-11-10T11:11:11Zpt_BR
dc.date.accessioned2011-11-10T11:11:11Zpt_BR
dc.date.available2011-11-10T11:11:11Zpt_BR
dc.date.available2011-11-10T11:11:11Zpt_BR
dc.date.created2011-11-10pt_BR
dc.date.issued2011pt_BR
dc.identifier.citationLipids in Health and Disease, v. 10, n. 165, 2011.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/905555pt_BR
dc.descriptionBackground: This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin), in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods: Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9): 1) standard (STD): fed on casein as protein source; 2) hypercholesterolemic (HC): STD plus 1% cholesterol and 0.5% cholic acid; 3) HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day); 4) HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day); 5) HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3) and (4). The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results: A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleSoybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2018-05-28T11:11:11Zpt_BR
dc.subject.thesagroSojapt_BR
riaa.ainfo.id905555pt_BR
riaa.ainfo.lastupdate2018-05-28 -03:00:00pt_BR
dc.contributor.institutionROBERTO WILLIANS NODA, CNPMS.pt_BR
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