Título:	Cis-9, trans-11 and trans-10, cis-12 CLA mixture does not change body composition, induces insulin resistance and increases serum HDL cholesterol level in rats.
Autoria:	ALMEIDA, M. M. de SOUZA, Y. O. de LUQUETTI, S. C. P. D. SABARENSE, C. M. CORRÊA, J. O. do A. CONCEIÇÃO, E. P. S. da LISBOA, P. C. MOURA, E. G. de SOARES, S. M. A. GUALBERTO, A. C. M. GAMEIRO, J. GAMA, M. A. S. da LOPES, F. C. F. GARCIA, R. M. G.
Afiliação:	Mariana Macedo de Almeida, UFJF; Yamara Oliveira de Souza, UFJF; Sheila Cristina Potente Dutra Luquetti, UFJF; Céphora Maria Sabarense, UFJF; José Otávio do Amaral Corrêa, UFJF; Ellen Paula Santos da Conceição, UERJ; Patrícia Cristina Lisboa, UERJ; Egberto Gaspar de Moura, UERJ; Sara Malaguti Andrade Soares, UFJF; Ana Cristina Moura Gualberto; Jacy Gameiro, UFJF; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; FERNANDO CESAR FERRAZ LOPES, CNPGL; Raúl Marcel González Garcia, UFJF.
Ano de publicação:	2015
Referência:	Journal of Oleo Science, v. 64, n. 5, p. 539-551, 2015.
Conteúdo:	Synthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture of cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety of this CLA mixture is controversial and in some countries the CLA usage as food supplement is not authorized. Changes in insulinemic control and serum lipids profile are potential negative effects related to consumption of CLA mixture. The present study aimed to evaluate the effects of a diet containing mixture of cis-9, trans-11 and trans-10, cis-12 CLA on prevention of obesity risk as well as on potential side effects such as insulin resistance and dyslipidemia in Wistar rats. Thirty male Wistar rats were randomly assigned to the following dietary treatments (n=10/group), for 60 days: Normolipidic Control (NC), diet containing 4.0% soybean oil (SO); High Fat-Control (HF-C), diet containing 24.0% SO; High Fat-synthetic CLA (HF-CLA), diet containing 1.5% of an isomeric CLA mixture (Luta-CLA 60) and 22.5% SO. Luta-CLA 60 (BASF) contained nearly 60% of CLA (cis-9, trans-11 and trans-10, cis-12 CLA at 50:50 ratio). The HF-CLA diet contained 0.3% of each CLA isomer. HF-CLA diet had no effect on dietary intake and body composition. HF-CLA-fed rats had lower levels of PPAR? protein in retroperitoneal adipose tissue, hyperinsulinemia compared to HF-C-fed rats, hyperglycemia compared to NC-fed rats while no differences in glycemia were observed between NC and HF-C groups, increased HOMA index and higher levels of serum HDL cholesterol. Thus, feeding rats with a high fat diet containing equal parts of cis-9, trans-11 and trans-10, cis-12 CLA isomers had no effect on body composition and induced insulin resistance. Despite HF-CLA-fed rats had increased serum HDL cholesterol levels, caution should be taken before synthetic supplements containing cis-9, trans-11 and trans-10, cis-12 CLA are recommended as a nutritional strategy for weight management.
NAL Thesaurus:	insulin resistance obesity
Palavras-chave:	Cis-9 Trans-11 CLA Trans-10 Cis-12 CLA Dyslipidemia
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPGL)