Title:	Genome-wide association analysis reveals insights into the genetic architecture of mesenteric torsion in pigs.
Authors:	PADILHA, S. F. MARTINS, R. HUL, L. M. CARREÑO, L. O. D. FREITAS, M. S. de LOPES, J. S. IBELLI, A. M. G. PEIXOTO, J. de O. MORES, M. A. Z. CANTAO, M. E. TEIXEIRA, R. de A. DIAS, L. T. LEDUR, M. C.
Affiliation:	SUELEN FERNANDES PADILHA, UNIVERSIDADE FEDERAL DO PARANÁ; RAFAELA MARTINS, UNIVERSIDADE FEDERAL DO PARANÁ; LUDMILA MUDRI HUL, UNIVERSIDADE ESTADUAL DO CENTRO-OESTE; LUIS ORLANDO DUITAMA CARREÑO, BRF; MARCELO SILVA DE FREITAS, BRF; JADER SILVA LOPES, BRF; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; JANE DE OLIVEIRA PEIXOTO, UNIVERSIDADE ESTADUAL DO CENTRO-OESTE; MARCOS ANTONIO ZANELLA MORES, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; RODRIGO DE ALMEIDA TEIXEIRA, UNIVERSIDADE FEDERAL DO PARANÁ; LAILA TALARICO DIAS, UNIVERSIDADE FEDERAL DO PARANÁ; MONICA CORREA LEDUR, CNPSA.
Date Issued:	2025
Citation:	Scientific Reports, v. 15, article number 13774, 2025.
Description:	Mesenteric torsion (MT) is a condition that affects several animal species and can lead to the animals’ death. However, little is known about its etiology. Therefore, this study aimed to identify genomic regions and candidate genes associated with MT. Phenotypic and genotypic data from 405 pigs, including MT records and genealogy were used. In the model, contemporary group (sex, year, and week of weaning) was considered fixed effect, the linear effect of weaning weight as a covariate, while direct additive genetic effect was random. In the genome-wide association study, genomic windows explaining more than 0.3% of the genetic variance were considered significant. Fifty-two significant windows were identified, covering 299 genes located on 15 chromosomes. The HSD17B4, TNFAIP8, TENM4, CHD2, RGMA, OPRM1, PPARGC1A, CHIA, KCNJ2, KCNJ16, KCNJ15, ELN, SGO1, IL17A, IL17F, GATA4, OVOL2, GLI3, and RAP1A genes were considered candidates to MT since they are related to intestinal morphogenesis, feeding behavior, intestinal barrier, digestion, and intestinal motility. These processes could induce intestinal malformations, dysbiosis, excessive fermentation, delay intestinal transit, and obstruction. Our findings contribute to understanding the mechanisms involved in the occurrence of MT in pigs and may help to elucidate the etiology of intestinal torsion/volvulus in other mammals, including humans.
Thesagro:	Porco Genoma Genética Animal
NAL Thesaurus:	Nervous system Finishing Volvulus Secretion Death
ISSN:	2045-2322
DOI:	https://doi.org/10.1038/s41598-025-98029-5
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPPSE)