Título:	In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants.
Autoria:	ANDRADE-NETO, V. F. de POHLIT, A. M. PINTO, A. C. S. SILVA, E. C. C. NOGUEIRA, K. L. MELO, M. R. S. HENRIQUE, M. C. AMORIM, R. C. N. SILVA, L. F. R. COSTA, M. R. F. NUNOMURA, R. C. S. NUNOMURA, S. M. ALECRIM, W. D. ALECRIM, M. das G. C. CHAVES, F. C. M. VIEIRA, P. P. R.
Afiliação:	Valter F. de Andrade-Neto, Inpa; Adrian M. Pohlit, Inpa; Ana Cristina S. Pinto, Inpa/Ufam; Ellen Cristina C. Silva, Inpa/Ufam; Karla L. Nogueira, Inpa/CEFET-AM; Márcia R.S. Melo, Inpa/FMTM; Marycleuma C. Henrique, Inpa/Ufam; Rodrigo C.N. Amorim, Inpa/Ufam; Luis Francisco R. Silva, FMTM; Mônica R.F. Costa, FMTM; Rita C.S. Nunomura, Inpa; Sergio M. Nunomura, Inpa; Wilson D. Alecrim, FMTM; Maria das Graças C. Alecrim, Inpa/UniNilton Lins; Francisco Célio Maia Chaves, CPAA; Pedro Paulo R. Vieira, UEA.
Ano de publicação:	2007
Referência:	Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 3, p. 359-365, jun. 2007.
Conteúdo:	In the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. This is the first report on the antimalarial activity of these known, natural compounds. This is also the first report on the isolation of aspidocarpine from A. desmanthum. These compounds are good candidates for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and lend support to the traditional use of the plants from which these compounds are derived.
Thesagro:	Planta
NAL Thesaurus:	Plasmodium falciparum Amazonia malaria
Palavras-chave:	Isolação in vitro
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CPAA)