Title:	Sublethal endpoints in non-target organism testing for insect-active GE crops.
Authors:	ROBERTS, A. BOECKMAN, C. J. MÜHL, M. ROMEIS, J. TEEM, J. L. VALICENTE, F. H. BROWN, J. K. EDWARDS, M. G. LEVINE, S. L. MELNICK, R. L. ROFRIGUES, T. B. VÉLEZ, A. M. ZHOU, X. HELLMICH, R. L.
Affiliation:	Andrew Roberts, Agriculture and Food Systems Institute, Washington, DC Chad J. Boeckman, Corteva Agriscience Marina Mühl, Ministerio de Agricultura, Ganadería y Pesca, Dirección de Biotecnología, Buenos Aires Jörg Romeis, Research Division Agroecology and Environment, Agroscope, Zurich John L. Teem, Agriculture and Food Systems Institute, Washington, DC FERNANDO HERCOS VALICENTE, CNPMS Judith K. Brown, School of Plant Sciences, The University of Arizona, Tucson Martin G. Edwards, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne Steven L. Levine, Bayer Crop Science, Chesterfield, MO Rachel L. Melnick, Agriculture and Food Systems Institute, Washington, DC Thais B. Rodrigues, Greenlight Biosciences, Inc., Medford, MA Ana M. Vélez, Department of Entomology, University of Nebraska-Lincoln Xuguo Zhou, Department of Entomology, University of Kentucky, Lexington, KY Richard L. Hellmich, USDA, Corn Insects and Crop Genetics Research Unit, Ames.
Date Issued:	2020
Citation:	Frontiers in Bioengineering and Biotechnology, v. 8, article 556, 2020.
Description:	Historically, genetically engineered (GE) plants that have incorporated genes conferring insect protection have primarily used Cry proteins derived from Bacillus thuringiensis (Bt) to achieve their insecticidal phenotype. As a result, regulators have developed a level of familiarity and confidence in reviewing plants incorporating these insecticidal proteins. However, new technologies have been developed that produce GE plants that incorporate pest protection by triggering an RNA interference (RNAi) response or proteins other than Bt Cry proteins. These technologies have new modes of action. Although the overall assessment paradigm for GE plants is robust, there are ongoing discussions about the appropriate tests and measurement endpoints needed to inform non-target arthropod assessment for technologies that have a different mode of action than the Bt Cry proteins. As a result, increasing attention is being paid to the use of sublethal endpoints and their value for environmental risk assessment (ERA). This review focuses on the current status and history of sublethal endpoint use in insect-active GE crops, and evaluates the future use of sublethal endpoints for new and emerging technologies. It builds upon presentations made at the Workshop on Sublethal Endpoints for Non-target Organism Testing for Non-Bt GE Crops (Washington DC, USA, 4â??5 March 2019), and the discussions of government, academic and industry scientists convened for the purpose of reviewing the progress and status of sublethal endpoint testing in non-target organisms.
Thesagro:	Melhoramento Genético Vegetal Controle Biológico Inseto Planta Transgênica
Keywords:	Organismos não-alvo Parâmetros subletais Planta geneticamente modificada
DOI:	https://doi.org/10.3389/fbioe.2020.00556
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPMS)