Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1153621
Título: Anthocyanins formulated with carboxymethyl starch for gastric and intestinal delivery.
Autoria: SABINO, L. B. de S.
COPES, F.
SAULAIS, S.
BRITO, E. S. de
SILVA JÚNIOR, I. J. da
LE, T. C.
MATEESCU, M. A.
MANTOVANI, D.
Afiliação: LUIZ BRUNO DE SOUSA SABINO, UFC; FRANCESCO COPES, Laval University; SOLÈNE SAULAIS, Université du Québec à Montréal; EDY SOUSA DE BRITO, CNAT; IVANILDO JOSÉ DA SILVA JÚNIOR, UFC; TIEN CANH LE, Université du Québec à Montréal; MIRCEA ALEXANDRU MATEESCU, Université du Québec à Montréal; DIEGO MANTOVANI, Laval University.
Ano de publicação: 2022
Referência: Molecules, v. 27, n. 21, 7271, p. 1-19, 2022.
Conteúdo: Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.
Thesagro: Fruto
Antiinflamatório
NAL Thesaurus: Anthocyanins
Syzygium cumini
Fruit composition
Palavras-chave: Carboxymethyl starch
Bioactive agent delivery
Monolithic tablets
Jamelão
Agente bioativo
Antioxidantes
Antitumoral
Antiaterosclerótica
Antioxidant activities
Antiinflammatory
Antiatherosclerotic activities
ISSN: 1420-3049
Digital Object Identifier: https://doi.org/10.3390/molecules27217271
Tipo do material: Artigo de periódico
Acesso: openAccess
Aparece nas coleções:Artigo em periódico indexado (CNAT)

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