Title:	LC-MS analysis and antifungal activity of Turnera subulata Sm.
Authors:	PINHEIRO, J. C. A. SOUZA, C. E. S. DE RIBEIRO, D. A. SILVA, A. DE A. SILVA, V. B. DA SANTOS, A. T. L. DOS FONSECA, V. J. A. MACÊDO, D. G. DE CRUZ, R. P. DA BEZERRA, J. W. A. MACHADO, A. J. T. FREITAS, T. S. DE BRITO, E. S. de RIBEIRO, P. R. V. COSTA, J. G. M. DA COUTINHO, H. D. M. KOWALSKA, G. ROWINSKI, R. KOWALSKI, R. BRAGA, M. F. B. M.
Affiliation:	JACQUELINE COSMO ANDRADE-PINHEIRO, Regional University of Cariri; CELESTINA ELBA SOBRAL DE SOUZA, Regional University of Cariri; DAIANY ALVES RIBEIRO, Regional University of Cariri; ANDRESSA DE ALENCAR SILVA, Regional University of Cariri; VIVIANE BEZERRA DA SILVA, Federal University of Pernambuco; ANTONIA THASSYA LUCAS DOS SANTOS, Regional University of Cariri; VICTOR JUNO ALENCAR FONSECA, Regional University of Cariri; DELMACIA GONÇALVES DE MACÊDO, Regional University of Cariri; RAFAEL PEREIRA DA CRUZ, Regional University of Cariri; JOSÉ WEVERTON ALMEIDA-BEZERRA, Regional University of Cariri; ANTONIO JÚDSON TARGINO MACHADO, Regional University of Cariri; THIAGO SAMPAIO DE FREITAS, Regional University of Cariri; EDY SOUSA DE BRITO, CNAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; JOSÉ GALBERTO MARTINS DA COSTA, Regional University of Cariri; HENRIQUE DOUGLAS MELO COUTINHO, Regional University of Cariri; GRAZYNA KOWALSKA, University of Life Sciences in Lublin; RAFAL ROWINSKI, University of Life Sciences in Lublin; RADOSLAW KOWALSKI, University of Life Sciences in Lublin; MARIA FLAVIANA BEZERRA MORAIS-BRAGA, Regional University of Cariri.
Date Issued:	2023
Citation:	Plants, v. 12, n. 415, 2023.
Pages:	12 p.
Description:	Fungi of the Candida genus are responsible for invasive candidiasis, which affects people all over the world and has high mortality rates. This is due to their virulence factors, which give them great resistance and pathogenicity. In addition, the emergence of multidrug-resistant strains makes it difficult to treat these infections. In this way, natural products have emerged as an alternative to standard drugs, where plants known for their medicinal properties such as Turnera subulata become attractive to research. The present work aimed to analyze the ethanol extract of Turnera subulata leaves against standard strains of Candida albicans, Candida krusei and Candida tropicalis using broth microdilution techniques. The identification of the compounds in T. subulata leaves by LC-MS revealed the presence of a wide variety of substances such as carboxylic acids and terpenes, with flavonoids and fatty acids being more evident. The antifungal assays showed that the extract was not able to inhibit the growth of the tested strains at concentrations with a clinical relevance. However, at higher concentrations, it was able to inhibit the fungal dimorphism of C. albicans and C. tropicalis. It is possible that the T. subulata extract has potential as an inhibitor of fungal virulence factors without affecting the cell viability. Further research should be carried out in order to assess its inhibitory potential for other fungal virulence factors.
NAL Thesaurus:	Yeasts Virulence
Keywords:	Extract Antifungal
DOI:	10.3390/plants12020415
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNAT)