Title:	Is a genome a codeword of an error-correcting code?
Authors:	FARIA, L. C. B. ROCHA, A. S. L. KLEINSCHMIDT, J. H. SILVA-FILHO, M. C. BIM, E. HERAI, R. H. YAMAGISHI, M. E. B. PALAZZO JÚNIOR, R.
Affiliation:	LUZINETE C. B. FARIA, UNIVERSIDADE ESTADUAL DE CAMPINAS ANDRÉA S. L. ROCHA, UNIVERSIDADE ESTADUAL DE CAMPINAS JOÃO H. KLEINSCHMIDT, UNIVERSIDADE FEDERAL DO ABC MÁRCIO C. SILVA-FILHO, UNIVERSIDADE DE SÃO PAULO EDSON BIM, UNIVERSIDADE ESTADUAL DE CAMPINAS ROBERTO H. HERAI, UNIVERSITY OF CALIFORNIA MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA REGINALDO PALAZZO JÚNIOR, UNIVERSIDADE ESTADUAL DE CAMPINAS.
Date Issued:	2012
Citation:	PLoS ONE, San Francisco, v. 7, n. 5, e105396, May 2012.
Description:	Since a genome is a discrete sequence, the elements of which belong to a set of four letters, the question as to whether or not there is an error-correcting code underlying DNA sequences is unavoidable. The most common approach to answering this question is to propose a methodology to verify the existence of such a code. However, none of the methodologies proposed so far, although quite clever, has achieved that goal. In a recent work, we showed that DNA sequences can be identified as codewords in a class of cyclic error-correcting codes known as Hamming codes. In this paper, we show that a complete intron-exon gene, and even a plasmid genome, can be identified as a Hamming code codeword as well. Although this does not constitute a definitive proof that there is an error-correcting code underlying DNA sequences, it is the first evidence in this direction.
Thesagro:	Biologia
NAL Thesaurus:	Genome Nucleotide sequences
Keywords:	Sequência de DNA Biology
DOI:	https://doi.org/10.1371/journal.pone.0036644
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CNPTIA)