Título:	Is a genome a codeword of an error-correcting code?
Autoria:	FARIA, L. C. B. ROCHA, A. S. L. KLEINSCHMIDT, J. H. SILVA-FILHO, M. C. BIM, E. HERAI, R. H. YAMAGISHI, M. E. B. PALAZZO JÚNIOR, R.
Afiliação:	LUZINETE C. B. FARIA, Unicamp; ANDRÉA S. L. ROCHA, Unicamp; JOÃO H. KLEINSCHMIDT, UFABC; MÁRCIO C. SILVA-FILHO, Esalq/USP; EDSON BIM, Unicamp; ROBERTO H. HERAI, University of California San Diego; MICHEL EDUARDO BELEZA YAMAGISHI, CNPTIA; REGINALDO PALAZZO JÚNIOR, Unicamp.
Ano de publicação:	2012
Referência:	PLoS ONE, San Francisco, v. 7, n. 5, p. 1-9, May 2012.
Conteúdo:	Since a genome is a discrete sequence, the elements of which belong to a set of four letters, the question as to whether or not there is an error-correcting code underlying DNA sequences is unavoidable. The most common approach to answering this question is to propose a methodology to verify the existence of such a code. However, none of the methodologies proposed so far, although quite clever, has achieved that goal. In a recent work, we showed that DNA sequences can be identified as codewords in a class of cyclic error-correcting codes known as Hamming codes. In this paper, we show that a complete intron-exon gene, and even a plasmid genome, can be identified as a Hamming code codeword as well. Although this does not constitute a definitive proof that there is an error-correcting code underlying DNA sequences, it is the first evidence in this direction.
Thesagro:	Biologia
NAL Thesaurus:	Genome Nucleotide sequences
Palavras-chave:	Sequência de DNA Biology
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CNPTIA)