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dc.contributor.authorBRESSANI, F. A.pt_BR
dc.contributor.authorTIZIOTO, P. C.pt_BR
dc.contributor.authorGIGLIOTI, R.pt_BR
dc.contributor.authorMEIRELLHES, S. L. C.pt_BR
dc.contributor.authorCOUTINHO, R.pt_BR
dc.contributor.authorBENVENUTI, C. L.pt_BR
dc.contributor.authorMALAGO JUNIOR, W.pt_BR
dc.contributor.authorMUDADU, M. de A.pt_BR
dc.contributor.authorVIEIRA, L. C.pt_BR
dc.contributor.authorZAROS, L. G.pt_BR
dc.contributor.authorCARRILHO, E.pt_BR
dc.contributor.authorREGITANO, L. C. de A.pt_BR
dc.date.accessioned2014-12-16T11:11:11Zpt_BR
dc.date.available2014-12-16T11:11:11Zpt_BR
dc.date.created2014-12-16pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationGenetics and Molecular Research, v. 13, n. 4, p. 8530-8436, 2014.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1002812pt_BR
dc.descriptionCytokines are small cell-signaling proteins that play an important role in the immune system, participating in intracellular communication. Four candidate genes of the cytokine family (IL2, IL4, IL13, and IFNG) were selected to identify Single Nucleotide Polymorphisms (SNPs) that might be associated with resistance to gastrointestinal endoparasites in goats. A population of 229 goats, F2 offspring from an F1 intercross was produced by crossing pure Saanen goats, considered as susceptible to gastrointestinal endoparasites, with pure Anglo-Nubian goats, considered resistant. Blood was collected for DNA extraction and fecal samples were also collected for parasite egg count. Polymorphisms were prospected by sequencing animals with extreme phenotype for fecal egg count (FEC) distribution. The association between SNPs and phenotype was determined by using the Fisher exact test with correction for multiple tests. Three of the 10 SNPs were identified as significant (P ≤ 0.03). They were found in intron 1 of IL2 (ENSBTA00000020883), intron 3 of IL13 (ENSBTA00000015953) and exon 3 of IFNG (ENSBTA00000012529), suggesting an association between them and gastrointestinal endoparasite resistance. Further studies will help describe the effects of these markers accurately before implementing them in marker assisted selection. This study is the pioneer in describing such associations in goats.eng
dc.language.isoengpt_BR
dc.rightsopenAccesspt_BR
dc.subjectCytokinept_BR
dc.subjectGastrointestinal infectionpt_BR
dc.titleSingle nucleotide polymorphisms in candidate genes associated with gastrointestinal nematode infection in goats.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2016-03-01T11:11:11Zpt_BR
dc.subject.thesagroCapra Hircuspt_BR
dc.subject.nalthesaurussingle nucleotide polymorphismpt_BR
riaa.ainfo.id1002812pt_BR
riaa.ainfo.lastupdate2016-03-01pt_BR
dc.identifier.doi10.4238/2014.October.20.29eng
dc.contributor.institutionFLAVIA ALINE BRESSANI, CPPSEpt_BR
dc.contributor.institutionP. C. TIZIOTO, Universidade Federal de São Carloseng
dc.contributor.institutionRODRIGO GIGLIOTI, Universidade Estadual Paulistaeng
dc.contributor.institutionS. L. C. MEIRELLES, Universidade Federal de Lavraseng
dc.contributor.institutionR. COUTINHO, Universidade Federal do Rio Grande do Norteeng
dc.contributor.institutionC. L. BENVENUTI, Universidade Federal do Rio Grande do Norteeng
dc.contributor.institutionWILSON MALAGO JUNIOR, CPPSEeng
dc.contributor.institutionMAURICIO DE ALVARENGA MUDADU, CPPSEeng
dc.contributor.institutionLUIS CARLOS VIEIRA, CNPCeng
dc.contributor.institutionL. G. ZAROS, Universidade Federal do Rio Grande do Norteeng
dc.contributor.institutionE. CARRILHO, Universidade de São Pauloeng
dc.contributor.institutionLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.eng
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