Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1003463
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorMOKRY, F. B.pt_BR
dc.contributor.authorBUZANSKAS, M. E.pt_BR
dc.contributor.authorMUDADU, M. de A.pt_BR
dc.contributor.authorGROSSI, D. do A.pt_BR
dc.contributor.authorHIGA, R. H.pt_BR
dc.contributor.authorVENTURA, R. V.pt_BR
dc.contributor.authorLIMA, A. O. dept_BR
dc.contributor.authorSARGOLZAEI, M.pt_BR
dc.contributor.authorMEIRELLES, S. L. C.pt_BR
dc.contributor.authorSCHENKEL, F. S.pt_BR
dc.contributor.authorSILVA, M. V. G. B. dapt_BR
dc.contributor.authorNICIURA, S. C. M.pt_BR
dc.contributor.authorALENCAR, M. M. dept_BR
dc.contributor.authorMINARI, D. P.pt_BR
dc.contributor.authorREGITANO, L. C. de A.pt_BR
dc.date.accessioned2014-12-22T11:11:11Zpt_BR
dc.date.available2014-12-22T11:11:11Zpt_BR
dc.date.created2014-12-22pt_BR
dc.date.issued2014pt_BR
dc.identifier.citationBMC Genomics, London, v. 15, p. 1-9, Oct. 2014.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1003463pt_BR
dc.descriptionAbstract. Background: The development of linkage disequilibrium (LD) maps and the characterization of haplotype block structure at the population level are useful parameters for guiding genome wide association (GWA) studies, and for understanding the nature of non-linear association between phenotypes and genes. The elucidation of haplotype block structure can reduce the information of several single nucleotide polymorphisms (SNP) into the information of a haplotype block, reducing the number of SNPs in a coherent way for consideration in GWA and genomic selection studies. Results: The maximum average LD, measured by r2 varied between 0.33 to 0.40 at a distance of < 2.5 kb, and the minimum average values of r2 varied between 0.05 to 0.07 at distances ranging from 400 to 500 kb, clearly showing that the average r2 reduced with the increase in SNP pair distances. The persistence of LD phase showed higher values at shorter genomic distances, decreasing with the increase in physical distance, varying from 0.96 at a distance of < 2.5 kb to 0.66 at a distance from 400 to 500 kb. A total of 78% of all SNPs were clustered into haplotype blocks, covering 1,57 Mb of the total autosomal genome size. Conclusions: This study presented the first high density linkage disequilibrium map and haplotype block structure for a composite beef cattle population, and indicates that the high density SNP panel over 700 k can be used for genomic selection implementation and GWA studies for Canchim beef cattle.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectPolimorfismo de nucleotídeo únicopt_BR
dc.subjectGenome wide association studiespt_BR
dc.subjectDesequilíbrio de ligaçãopt_BR
dc.titleLinkage disequilibrium and haplotype block structure in a composite beef cattle breed.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2014-12-24T11:11:11Zpt_BR
dc.subject.thesagroGado de cortept_BR
dc.subject.nalthesaurusBeef cattlept_BR
dc.subject.nalthesaurusSingle nucleotide polymorphismpt_BR
dc.subject.nalthesaurusLinkage disequilibriumpt_BR
dc.description.notesSuppl 7.pt_BR
riaa.ainfo.id1003463pt_BR
riaa.ainfo.lastupdate2014-12-24pt_BR
dc.identifier.doi10.1186/1471-2164-15-S7-S6pt_BR
dc.contributor.institutionFABIANA BARICHELLO MOKRY, UFSCar; MARCOS ELI BUZANSKAS, FCAV/Unesp; MAURICIO DE ALVARENGA MUDADU, CPPSE; DANIELA DO AMARAL GROSSI, University of Guelph; ROBERTO HIROSHI HIGA, CNPTIA; RICARDO VIEIRA VENTURA, University of Guelph; ANDRESSA OLIVIERA DE LIMA, UFSCar; MENDI SARGOLZAEI, University of Guelph; SARAH LUGUNA CONCEIÇÃO MEIRELLES, UFV; FLÁVIO SCHRAMM SCHENKEL, University of Guelph; MARCOS VINICIUS GUALBERTO BARBOSA DA SILVA, CNPGL; SIMONE CRISTINA MÉO NICIURA, CPPSE; MAURICIO MELLO DE ALENCAR, CPPSE; DANÍSIO PRADO MUNARI, FCAV/Unesp; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.pt_BR
Aparece nas coleções:Artigo em periódico indexado (CNPTIA)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
1471216415S7S6.pdf2,41 MBAdobe PDFThumbnail
Visualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas

FacebookTwitterDeliciousLinkedInGoogle BookmarksMySpace