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dc.contributor.authorANDREOTE, A. P. D.
dc.contributor.authorROSÁRIO, M. F. do
dc.contributor.authorLEDUR, M. C.
dc.contributor.authorJORGE, E. C.
dc.contributor.authorSONSTEGARD, T. S.
dc.contributor.authorMATUKUMALLI, L.
dc.contributor.authorCOUTINHO, L. L.
dc.date.accessioned2018-01-26T23:41:35Z-
dc.date.available2018-01-26T23:41:35Z-
dc.date.created2015-04-07
dc.date.issued2014
dc.identifier.citationGenetics and Molecular Research, v. 6, n. 1, p. 1465-1479, 2014.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1012924-
dc.descriptionMicroRNAs (miRNAs, miRs) encompass a class of small non-coding RNAs that often negatively regulate gene expression. miRNAs play an essential role in skeletal muscle, determining the proper development and maintenance of this tissue. In comparison to other organs and tissues, the full set of muscle miRNAs and its expression patterns are still poorly understood. In this report, a chicken skeletal muscle miRNA library was constructed, and the expression of selected miRNAs was further characterized during muscle development in chicken lines with distinct muscling phenotypes. Clone library sequence analysis revealed 40 small RNAs with similarities to previously described chicken miRNAs, seven miRNAs that were never identified before in chicken, and some sequence clusters representing other possible novel miRNAs. Temporal expression profiles of three miRNAs associated with cell proliferation and differentiation (miR-125b, miR-221, and miR-206) in two chicken lines (broiler and layer) revealed the differential steady-state levels of these miRs during skeletal muscle growth and suggests that miR-206 is involved in the muscling phenotype that is observed in growth-selected chicken lines.
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleIdentification and characterization of microRNAs expressed in chicken skeletal muscle.
dc.typeArtigo de periódico
dc.date.updated2018-01-26T23:41:35Zpt_BR
dc.subject.thesagroGenetica animal
dc.subject.thesagroGalinha
dc.subject.nalthesaurusChickens
dc.subject.nalthesaurusMolecular genetics
dc.subject.nalthesaurusCell proliferation
riaa.ainfo.id1012924
riaa.ainfo.lastupdate2018-01-26
dc.identifier.doi10.4238/2014.March.6.5.
dc.contributor.institutionANA PAULA DINI ANDREOTE, CENA/USP; MILLOR FERNANDES DO ROSÁRIO, ESALQ; MONICA CORREA LEDUR, CNPSA; ERIKA CRISTINA JORGE, CENA/USP; Animal Research Center/USDA; Animal Research Center/USDA; LUIS LEHMANN COUTINHO, ESALQ.
Aparece nas coleções:Artigo em periódico indexado (CNPSA)

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