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dc.contributor.authorAZEVEDO, C. F.pt_BR
dc.contributor.authorRESENDE, M. D. V. dept_BR
dc.contributor.authorSILVA, F. F. ept_BR
dc.contributor.authorVIANA, J. M. S.pt_BR
dc.contributor.authorVALENTE, M. S. F.pt_BR
dc.contributor.authorRESENDE JUNIOR, M. F. R.pt_BR
dc.contributor.authorMUÑOZ, P.pt_BR
dc.date.accessioned2015-08-24T11:11:11Zpt_BR
dc.date.available2015-08-24T11:11:11Zpt_BR
dc.date.created2015-08-24pt_BR
dc.date.issued2015pt_BR
dc.identifier.citationBMC Genetics, v. 16, art. 105, Aug. 2015. 13 p.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1022575pt_BR
dc.descriptionBackground: A complete approach for genome-wide selection (GWS) involves reliable statistical genetics models and methods. Reports on this topic are common for additive genetic models but not for additive-dominance models. The objective of this paper was (i) to compare the performance of 10 additive-dominance predictive models (including current models and proposed modifications), fitted using Bayesian, Lasso and Ridge regression approaches; and (ii) to decompose genomic heritability and accuracy in terms of three quantitative genetic information sources, namely, linkage disequilibrium (LD), co-segregation (CS) and pedigree relationships or family structure (PR). The simulation study considered two broad sense heritability levels (0.30 and 0.50, associated with narrow sense heritabilities of 0.20 and 0.35, respectively) and two genetic architectures for traits (the first consisting of small gene effects and the second consisting of a mixed inheritance model with five major genes). Results: G-REML/G-BLUP and a modified Bayesian/Lasso (called BayesA*B* or t-BLASSO) method performed best in the prediction of genomic breeding as well as the total genotypic values of individuals in all four scenarios (two heritabilities x two genetic architectures). The BayesA*B*-type method showed a better ability to recover the dominance variance/additive variance ratio. Decomposition of genomic heritability and accuracy revealed the following descending importance order of information: LD, CS and PR not captured by markers, the last two being very close. Conclusions: Amongst the 10 models/methods evaluated, the G-BLUP, BAYESA*B* (−2,8) and BAYESA*B* (4,6) methods presented the best results and were found to be adequate for accurately predicting genomic breeding and total genotypic values as well as for estimating additive and dominance in additive-dominance genomic models.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectModelo Bayesianopt_BR
dc.subjectGenética quantitativapt_BR
dc.subjectMelhoramento genéticopt_BR
dc.subjectDominance genomic modelspt_BR
dc.subjectBayesian methodspt_BR
dc.subjectLasso methodspt_BR
dc.subjectSelection accuracypt_BR
dc.titleRidge, Lasso and Bayesian additive dominance genomic models.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2016-02-25T11:11:11Zpt_BR
dc.subject.thesagroParâmetro Genéticopt_BR
riaa.ainfo.id1022575pt_BR
riaa.ainfo.lastupdate2016-02-25pt_BR
dc.identifier.doi10.1186/s12863-015-0264-2pt_BR
dc.contributor.institutionCamila Ferreira Azevedo, UFV; MARCOS DEON VILELA DE RESENDE, CNPF; Fabyano Fonseca e Silva, UFV; José Marcelo Soriano Viana, UFV; Magno Sávio Ferreira Valente, UFV; Márcio Fernando Ribeiro Resende Jr, Florida Innovation Hub; Patricio Muñoz, University of Florida.pt_BR
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