Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1032877
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dc.contributor.authorCUNICO, M. M.pt_BR
dc.contributor.authorTREBIEN, H. A.pt_BR
dc.contributor.authorGALETTI, F. C.pt_BR
dc.contributor.authorMIGUEL, O. G.pt_BR
dc.contributor.authorMIGUEL, M. D.pt_BR
dc.contributor.authorAUER, C. G.pt_BR
dc.contributor.authorSILVA, C. L.pt_BR
dc.contributor.authorSOUZA, A. O. dept_BR
dc.date.accessioned2016-01-05T11:11:11Zpt_BR
dc.date.available2016-01-05T11:11:11Zpt_BR
dc.date.created2016-01-05pt_BR
dc.date.issued2015pt_BR
dc.identifier.citationAnais da Academia Brasileira de Ciências, v. 87, n. 4, p. 1991-2000, 2015.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1032877pt_BR
dc.descriptionOttonia martiana is a plant popularly known in Brazil by the use for toothache. Ethanolic extract (EE), hexane fraction (HF), dichloromethane fraction (DF) and piperovatine obtained from O. martiana were assayed in vitro and in vivo. The acute toxicity of EE was determined, and LD50 values of 164.5 and 65.0 mg/ kg by the oral and intraperitoneal routes, respectively, indicated a high toxicity for EE in vivo, explaining its popular use by topical administration only. A local anesthetic-like effect of EE and its fractions was observed in experimental models using pain induction, and such effect involved an analgesic action. The antimycobacterial activity of EE, HF, DF and piperovatine was evaluated against Mycobacterium tuberculosis H37Rv ATCC 27924. EE, HF, DF, and piperovatine showed a potential antimycobacterial effect with MICs of 16.0, 62.0, 62.0 and 8.0 ?g/mL, respectively. Piperovatine was more effective than the EE or the other fractions. The selectivity index (SI=IC50/MIC) values calculated for EE, HF, DF and piperovatine based on the MICs and the cytotoxicity against J774 macrophages (IC50 by MTT assay) revealed values of 6.43, 2.34, 1.5 and 9.66, respectively.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectOttonia martianapt_BR
dc.subjectAnalgésicopt_BR
dc.subjectAntimicobacterialpt_BR
dc.subjectPiperovatinapt_BR
dc.subjectToxicidadept_BR
dc.subjectAnalgesicpt_BR
dc.subjectAnestheticpt_BR
dc.subjectAntimycobacterialpt_BR
dc.subjectPiperovatinept_BR
dc.titleInvestigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae).pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2016-02-04T11:11:11Zpt_BR
dc.subject.thesagroAnestésicopt_BR
dc.subject.thesagroEspécie Nativapt_BR
riaa.ainfo.id1032877pt_BR
riaa.ainfo.lastupdate2016-02-04pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/0001-3765201520140090pt_BR
dc.contributor.institutionMIRIAM M. CUNICO, UFPR; HERBERT A. TREBIEN, UFPR; FÁBIO C. GALETTI, USP; OBDULIO G. MIGUEL, UFPR; MARILIS D. MIGUEL, UFPR; CELSO GARCIA AUER, CNPF; CÉLIO L. SILVA, USP; ANA OLÍVIA DE SOUZA, Instituto Butantan.pt_BR
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