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dc.contributor.authorKIM, E. S.pt_BR
dc.contributor.authorSONSTEGARD, T. S.pt_BR
dc.contributor.authorSILVA, M. V. G. B.pt_BR
dc.contributor.authorGASBARRE, L. C.pt_BR
dc.contributor.authorTASSEL, C. P. V.pt_BR
dc.date.accessioned2016-02-16T11:11:11Zpt_BR
dc.date.available2016-02-16T11:11:11Zpt_BR
dc.date.created2016-02-16pt_BR
dc.date.issued2015pt_BR
dc.identifier.citationPLoS One, v. 10, n. 3, : e0119380, 2015.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1037193pt_BR
dc.descriptionGenetic markers associated with parasite indicator traits are ideal targets for study of marker assisted selection aimed at controlling infections that reduce herd use of anthelminthics. For this study, we collected gastrointestinal (GI) nematode fecal egg count (FEC) data from post-weaning animals of an Angus resource population challenged to a 26 week natural exposure on pasture. In all, data from 487 animals was collected over a 16 year period between 1992 and 2007, most of which were selected for a specific DRB1 allele to reduce the influence of potential allelic variant effects of the MHC locus. A genome-wide association study (GWAS) based on BovineSNP50 genotypes revealed six genomic regions located on bovine Chromosomes 3, 5, 8, 15 and 27; which were significantly associated (-log10 p=4.3) with Box-Cox transformed mean FEC (BC-MFEC). DAVID analysis of the genes within the significant genomic regions suggested a correlation between our results and annotation for genes involved in inflammatory response to infection. Furthermore, ROH and selection signature analyses provided strong evidence that the genomic regions associated BC-MFEC have not been affected by local autozygosity or recent experimental selection. These findings provide useful information for parasite resistance prediction for young grazing cattle and suggest new candidate gene targets for development of disease-modifying therapies or future studies of host response to GI parasite infection.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.titleGenome-wide scan of gastrointestinal nematode resistance in closed Angus population selected for minimized influence of MHC.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2016-03-14T11:11:11Zpt_BR
dc.subject.nalthesauruscattlept_BR
dc.subject.nalthesaurusgenetic markerspt_BR
dc.subject.nalthesaurusheritabilitypt_BR
dc.format.extent218 p.pt_BR
riaa.ainfo.id1037193pt_BR
riaa.ainfo.lastupdate2016-03-14pt_BR
dc.contributor.institutionEui-Soo Kim; Tad S. Sonstegard; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; Louis C. Gasbarre; Curtis P. Van Tassell.pt_BR
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