Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1037559
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dc.contributor.authorALMEIDA, M. M. dept_BR
dc.contributor.authorSOUZA, Y. O. dept_BR
dc.contributor.authorLUQUETTI, S. C. P. D.pt_BR
dc.contributor.authorSABARENSE, C. M.pt_BR
dc.contributor.authorCORRÊA, J. O. do A.pt_BR
dc.contributor.authorCONCEIÇÃO, E. P. S. dapt_BR
dc.contributor.authorLISBOA, P. C.pt_BR
dc.contributor.authorMOURA, E. G. dept_BR
dc.contributor.authorSOARES, S. M. A.pt_BR
dc.contributor.authorGUALBERTO, A. C. M.pt_BR
dc.contributor.authorGAMEIRO, J.pt_BR
dc.contributor.authorGAMA, M. A. S. dapt_BR
dc.contributor.authorLOPES, F. C. F.pt_BR
dc.contributor.authorGARCIA, R. M. G.pt_BR
dc.date.accessioned2016-02-18T11:11:11Zpt_BR
dc.date.available2016-02-18T11:11:11Zpt_BR
dc.date.created2016-02-18pt_BR
dc.date.issued2015pt_BR
dc.identifier.citationJournal of Oleo Science, v. 64, n. 5, p. 539-551, 2015.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1037559pt_BR
dc.descriptionSynthetic supplements of conjugated linoleic acid (CLA) containing 50:50 mixture of cis-9, trans-11 and trans-10, cis-12 CLA isomers have been commercialized in some places for reducing body fat. However the safety of this CLA mixture is controversial and in some countries the CLA usage as food supplement is not authorized. Changes in insulinemic control and serum lipids profile are potential negative effects related to consumption of CLA mixture. The present study aimed to evaluate the effects of a diet containing mixture of cis-9, trans-11 and trans-10, cis-12 CLA on prevention of obesity risk as well as on potential side effects such as insulin resistance and dyslipidemia in Wistar rats. Thirty male Wistar rats were randomly assigned to the following dietary treatments (n=10/group), for 60 days: Normolipidic Control (NC), diet containing 4.0% soybean oil (SO); High Fat-Control (HF-C), diet containing 24.0% SO; High Fat-synthetic CLA (HF-CLA), diet containing 1.5% of an isomeric CLA mixture (Luta-CLA 60) and 22.5% SO. Luta-CLA 60 (BASF) contained nearly 60% of CLA (cis-9, trans-11 and trans-10, cis-12 CLA at 50:50 ratio). The HF-CLA diet contained 0.3% of each CLA isomer. HF-CLA diet had no effect on dietary intake and body composition. HF-CLA-fed rats had lower levels of PPAR? protein in retroperitoneal adipose tissue, hyperinsulinemia compared to HF-C-fed rats, hyperglycemia compared to NC-fed rats while no differences in glycemia were observed between NC and HF-C groups, increased HOMA index and higher levels of serum HDL cholesterol. Thus, feeding rats with a high fat diet containing equal parts of cis-9, trans-11 and trans-10, cis-12 CLA isomers had no effect on body composition and induced insulin resistance. Despite HF-CLA-fed rats had increased serum HDL cholesterol levels, caution should be taken before synthetic supplements containing cis-9, trans-11 and trans-10, cis-12 CLA are recommended as a nutritional strategy for weight management.pt_BR
dc.language.isoporpt_BR
dc.rightsopenAccesspt_BR
dc.subjectCis-9pt_BR
dc.subjectTrans-11 CLApt_BR
dc.subjectTrans-10pt_BR
dc.subjectCis-12 CLApt_BR
dc.subjectDyslipidemiapt_BR
dc.titleCis-9, trans-11 and trans-10, cis-12 CLA mixture does not change body composition, induces insulin resistance and increases serum HDL cholesterol level in rats.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2016-04-15T11:11:11Zpt_BR
dc.subject.nalthesaurusinsulin resistancept_BR
dc.subject.nalthesaurusobesitypt_BR
riaa.ainfo.id1037559pt_BR
riaa.ainfo.lastupdate2016-04-15pt_BR
dc.contributor.institutionMariana Macedo de Almeida, UFJF; Yamara Oliveira de Souza, UFJF; Sheila Cristina Potente Dutra Luquetti, UFJF; Céphora Maria Sabarense, UFJF; José Otávio do Amaral Corrêa, UFJF; Ellen Paula Santos da Conceição, UERJ; Patrícia Cristina Lisboa, UERJ; Egberto Gaspar de Moura, UERJ; Sara Malaguti Andrade Soares, UFJF; Ana Cristina Moura Gualberto; Jacy Gameiro, UFJF; MARCO ANTONIO SUNDFELD DA GAMA, CNPGL; FERNANDO CESAR FERRAZ LOPES, CNPGL; Raúl Marcel González Garcia, UFJF.pt_BR
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