Título:	A single nucleotide polymorphism in NEUROD1 is associated with production traits in nelore beef cattle.
Autoria:	OLIVEIRA, P. P. A. TIZIOTO, P. C. MALAGO JUNIOR, W. NASCIMENTO, M. L. do CESAR, A. S. M. DINIZ, W. J. da S. SOUZA, M. M. de LANNA, D. P. D. TULLIO, R. R. MOURAO, G. B. MUDADU, M. de A. COUTINHO, L. L. REGITANO, L. C. de A.
Afiliação:	PATRICIA PERONDI ANCHAO OLIVEIRA, CPPSE; Polyana Cristine Tizioto, UFSCar; WILSON MALAGO JUNIOR, CPPSE; Michele Lopes do Nascimento, USP; Aline Silva Mello Cesar, USP; Wellison Jarles da Silva Diniz, UFSCar; Marcela Maria de Souza, UFSCar; Dante Pazzanese Duarte Lanna, USP; RYMER RAMIZ TULLIO, CPPSE; Gerson Barreto Mourão, USP; MAURICIO DE ALVARENGA MUDADU, CNPTIA; Luiz Lehmann Coutinho, USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Ano de publicação:	2016
Referência:	Genetics and Molecular Research, v. 15, n. 2, p. 1-8, 2016.
Conteúdo:	Feed efficiency and carcass characteristics are late-measured traits. The detection of molecular markers associated with them can help breeding programs to select animals early in life, and to predict breeding values with high accuracy. The objective of this study was to identify polymorphisms in the functional and positional candidate gene NEUROD1 (neurogenic differentiation 1), and investigate their associations with production traits in reference families of Nelore cattle. A total of 585 steers were used, from 34 sires chosen to represent the variability of this breed. By sequencing 14 animals with extreme residual feed intake (RFI) values, seven single nucleotide polymorphisms (SNPs) in NEUROD1 were identified. The investigation of marker effects on the target traits RFI, backfat thickness (BFT), ribeye area (REA), average body weight (ABW), and metabolic body weight (MBW) was performed with a mixed model using the restricted maximum likelihood method. SNP1062, which changes cytosine for guanine, had no significant association with RFI or REA. However, we found an additive effect on ABW (P ≤ 0.05) and MBW (P ≤ 0.05), with an estimated allele substitution effect of -1.59 and -0.93 kg0.75, respectively. A dominant effect of this SNP for BFT was also found (P ≤ 0.010). Our results are the first that identify NEUROD1 as a candidate that affects BFT, ABW, and MBW. Once confirmed, the inclusion of this SNP in dense panels may improve the accuracy of genomic selection for these traits in Nelore beef cattle as this SNP is not currently represented on SNP chips.
Thesagro:	Bos Indicus
NAL Thesaurus:	body composition
Palavras-chave:	Candidate gene Feed efficiency
Digital Object Identifier:	10.4238/gmr.15028161
Tipo do material:	Artigo de periódico
Acesso:	openAccess
Aparece nas coleções:	Artigo em periódico indexado (CPPSE)