Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1063533
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dc.contributor.authorGOMIDE, M.pt_BR
dc.contributor.authorLEMOS, F.pt_BR
dc.contributor.authorREIS, D. R. de L.pt_BR
dc.contributor.authorJOSÉ, G.pt_BR
dc.contributor.authorLOPES, M.pt_BR
dc.contributor.authorMACHADO, M. A.pt_BR
dc.contributor.authorALVES, T.pt_BR
dc.contributor.authorCOELHO, C. M.pt_BR
dc.date.accessioned2017-02-10T11:11:11Zpt_BR
dc.date.available2017-02-10T11:11:11Zpt_BR
dc.date.created2017-02-10pt_BR
dc.date.issued2016pt_BR
dc.identifier.citationRevista Brasileira de Farmacognosia, v. 26, n. 5, p. 627-633, 2016.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1063533pt_BR
dc.descriptionIn spite of advances in colorectal cancer treatments, approximately 1.4 million new global cases are estimated for 2015. In this sense, Brazilian plant diversity offers a multiplicity of essential oils as prospective novel anticancer compounds. This study aimed to evaluate the antiproliferative effect of the essential oils from four Lippia species in CT26.WT colon tumor cells, as a measurement of cell cycle phase distribution and microRNA expression. CT26.WT showed cell cycle arrest at G2/M phase after treatment with 100 g/ml of Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Lippia sidoides Cham., and Lippia lacunosa Mart. & Schauer, Verbenaceae, essential oils and, at the same concentration, Lippia rotundifolia Cham. essential oil caused an augment of G0/G1 phase. The miRNA expression profiling shows change of expression in key oncogenic miRNAs genes after treatment. Our findings suggest growth inhibition mechanisms for all four essential oils on CT26.WT cells involving direct or indirect interference on cell cycle arrest and/or oncogenic miRNAs expression.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectColorectal cancerpt_BR
dc.subjectCT26WTpt_BR
dc.subjectLippia essential oilpt_BR
dc.subjectCell cycle phasespt_BR
dc.titleIdentification of dysregulated microRNA expression and their potential role in the antiproliferative effect of the essential oils from four different Lippia species against the CT26.WT colon tumor cell line.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-02-10T11:11:11Zpt_BR
dc.subject.nalthesaurusmicroRNApt_BR
riaa.ainfo.id1063533pt_BR
riaa.ainfo.lastupdate2017-02-10pt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.bjp.2016.04.003eng
dc.contributor.institutionMayna Gomide, UFJFpt_BR
dc.contributor.institutionFernanda Lemos, UFMGeng
dc.contributor.institutionDANIELE RIBEIRO DE LIMA REIS FAZA, CNPGLeng
dc.contributor.institutionGustavo José, UnBeng
dc.contributor.institutionMiriam Lopes, UFMGeng
dc.contributor.institutionMARCO ANTONIO MACHADO, CNPGLeng
dc.contributor.institutionTânia Alves, Fundação Oswaldo Cruzeng
dc.contributor.institutionCíntia Marques Coelho, UFJFeng
dc.contributor.institutionUnB.eng
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