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dc.contributor.authorBARBOSA, J. O.pt_BR
dc.contributor.authorROSSONI, R. D.pt_BR
dc.contributor.authorVILELA, S. F. G.pt_BR
dc.contributor.authorALVARENGA, J. A. dept_BR
dc.contributor.authorVELLOSO, M. dos S.pt_BR
dc.contributor.authorPRATA, M. C. de A.pt_BR
dc.contributor.authorJORGE, A. O. C.pt_BR
dc.contributor.authorJUNQUEIRA, J. C.pt_BR
dc.date.accessioned2017-02-14T11:11:11Zpt_BR
dc.date.available2017-02-14T11:11:11Zpt_BR
dc.date.created2017-02-14pt_BR
dc.date.issued2016pt_BR
dc.identifier.citationPlos One, v. 11, n. 3, e0150457, 2016.pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1064049pt_BR
dc.descriptionAbstract Streptococcus mutans and Candida albicans are found together in the oral biofilms on dental surfaces, but little is known about the ecological interactions between these species. Here, we studied the effects of S. mutans UA159 on the growth and pathogencity of C. albicans. Initially, the effects of S. mutans on the biofilm formation and morphogenesis of C. albicans were tested in vitro. Next, we investigate the influence of S. mutans on pathogenicity of C. albicans using in vivo host models, in which the experimental candidiasis was induced in G. mellonella larvae and analyzed by survival curves, C. albicans count in hemolymph, and quantification of hyphae in the host tissues. In all the tests, we evaluated the direct effects of S. mutans cells, as well as the indirect effects of the subproducts secreted by this microorganism using a bacterial culture filtrate. The in vitro analysis showed that S. mutans cells favored biofilm formation by C. albicans. However, a reduction in biofilm viable cells and inhibition of hyphal growth was observed when C. albicans was in contact with the S. mutans culture filtrate. In the in vivo study, injection of S. mutans cells or S. mutans culture filtrate into G. mellonella larvae infected with C. albicans increased the survival of these animals. Furthermore, a reduction in hyphal formation was observed in larval tissues when C. albicans was associated with S. mutans culture filtrate. These findings suggest that S. mutans can secrete subproducts capable to inhibit the biofilm formation, morphogenesis and pathogenicity of C. albicans, attenuating the experimental candidiasis in G. mellonella model.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectPatologypt_BR
dc.subjectBiosupressionpt_BR
dc.subjectBiofilmspt_BR
dc.titleStreptococcus mutans can modulate biofilm formation and attenuate the virulence of Candida albicans.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-02-14T11:11:11Zpt_BR
dc.subject.nalthesaurusmicrobiologypt_BR
riaa.ainfo.id1064049pt_BR
riaa.ainfo.lastupdate2017-02-14pt_BR
dc.contributor.institutionJúnia Oliveira Barbosa, UNESP; Rodnei Dennis Rossoni, UNESP; Simone Furgeri Godinho Vilela, UNESP; Janaína Araújo de Alvarenga, UNESP; Marisol dos Santos Velloso, UNESP; MARCIA CRISTINA DE AZEVEDO PRATA, CNPGL; Antonio Olavo Cardoso Jorge, UNESP; Juliana Campos Junqueira, UNESP.pt_BR
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