Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1066092
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dc.contributor.authorSANTANA, M. H. de A.pt_BR
dc.contributor.authorOLIVEIRA JUNIOR, G. A.pt_BR
dc.contributor.authorCESAR, A. S. M.pt_BR
dc.contributor.authorFREUA, M. C.pt_BR
dc.contributor.authorGOMES, R. da C.pt_BR
dc.contributor.authorSILVA, S. da L.pt_BR
dc.contributor.authorLEME, P. R.pt_BR
dc.contributor.authorFUKUMASU, H.pt_BR
dc.contributor.authorCARVALHO, M. E.pt_BR
dc.contributor.authorVENTURA, R. V.pt_BR
dc.contributor.authorCOUTINHO, L. L.pt_BR
dc.contributor.authorKADARMIDEEN, H. N.pt_BR
dc.contributor.authorFERRAZ, J. B. S.pt_BR
dc.date.accessioned2017-03-03T11:11:11Zpt_BR
dc.date.available2017-03-03T11:11:11Zpt_BR
dc.date.created2017-03-03pt_BR
dc.date.issued2016pt_BR
dc.identifier.citationJournal of Applied Gentics, v. 57, n. 4, p. 495-504, 2016pt_BR
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1066092pt_BR
dc.descriptionThe use of genome-wide association results combined with other genomic approaches may uncover genes and metabolic pathways related to complex traits. In this study, the phenotypic and genotypic data of 1475 Nellore (Bos indicus) cattle and 941,033 single nucleotide polymorphisms (SNPs) were used for genome-wide association study (GWAS) and copy number variations (CNVs) analysis in order to identify candidate genes and putative pathways involved with the feed conversion ratio (FCR). The GWAS was based on the Bayes B approach analyzing genomic windows with multiple regression models to estimate the proportion of genetic variance explained by each window. The CNVs were detected with PennCNV software using the log R ratio and B allele frequency data. CNV regions (CNVRs) were identified with CNVRuler and a linear regression was used to associate CNVRs and the FCR. Functional annotation of associated genomic regions was performed with the Database for Annotation, Visualization and Integrated Discovery (DAVID) and the metabolic pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes (KEGG). We showed five genomic windows distributed over chromosomes 4, 6, 7, 8, and 24 that explain 12 % of the total genetic variance for FCR, and detected 12 CNVRs (chromosomes 1, 5, 7, 10, and 12) significantly associated [false discovery rate (FDR) < 0.05] with the FCR. Significant genomic regions (GWAS and CNV) harbor candidate genes involved in pathways related to energetic, lipid, and protein metabolism. The metabolic pathways found in this study are related to processes directly connected to feed efficiency in beef cattle. It was observed that, even though different genomic regions and genes were found between the two approaches (GWAS and CNV), the metabolic processes covered were related to each other. Therefore, a combination of the approaches complement each other and lead to a better understanding of the FCR.pt_BR
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectNellore cattlept_BR
dc.subjectGWASpt_BR
dc.titleCopy number variations and genome-wide associations reveal putative genes and metabolic pathways involved with the feed conversion ratio in beef cattle.pt_BR
dc.typeArtigo de periódicopt_BR
dc.date.updated2017-03-03T11:11:11Zpt_BR
dc.subject.nalthesaurusCattlept_BR
dc.subject.nalthesaurusFeed conversionpt_BR
dc.subject.nalthesaurusGenomicspt_BR
dc.subject.nalthesaurusCucumber necrosis viruspt_BR
dc.subject.nalthesaurusSingle nucleotide polymorphismpt_BR
riaa.ainfo.id1066092pt_BR
riaa.ainfo.lastupdate2017-03-03pt_BR
dc.contributor.institutionMIGUEL HENRIQUE DE ALMEIDA SANTANA; GERSON ANTÔNIO OLIVEIRA JUNIOR; ALINE SILVA MELLO CESAR; MATEUS CASTELANI FREUA; RODRIGO DA COSTA GOMES, CNPGC; SAULO DA LUZ E SILVA; PAULO ROBERTO LEME; HEIDGE FUKUMASU; MINOS ESPERÂNDIO CARVALHO; RICARDO VIEIRA VENTURA; LUIZ LEHMANN COUTINHO; HAJA N. KADARMIDEEN; JOSÉ BENTO STERMAN FERRAZ.pt_BR
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