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dc.contributor.authorBUZANSKAS, M. E.
dc.contributor.authorGROSSI, D. do A.
dc.contributor.authorVENTURA, R. V.
dc.contributor.authorSCHENKEL, F. S.
dc.contributor.authorCHUD, T. C. S.
dc.contributor.authorSTAFUZZA, N. B.
dc.contributor.authorROLA, L. D.
dc.contributor.authorMEIRELLES, S. L. C.
dc.contributor.authorMOKRY, F. B.
dc.contributor.authorMUDADU, M. de A.
dc.contributor.authorHIGA, R. H.
dc.contributor.authorSILVA, M. V. G. B.
dc.contributor.authorALENCAR, M. M. de
dc.contributor.authorREGITANO, L. C. de A.
dc.contributor.authorMUNARI, D. P.
dc.date.accessioned2017-08-25T19:12:14Z-
dc.date.available2017-08-25T19:12:14Z-
dc.date.created2017-08-23
dc.date.issued2017
dc.identifier.citationJournal of Animal Science and Biotechnology, v. 8, p. 1-10, 2017.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1074373pt_BR
dc.descriptionBackground: Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 animals. Results: Associated SNPs were observed for scrotal circumference at 420 d of age (435 SNPs), followed by scrotal circumference at 210 d of age (12 SNPs), age at first calving (six SNPs), and age at second calving (four SNPs). We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and reproduction. Conclusions: Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless, the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, all relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectPolimorfismo de nucleotídeo único
dc.titleCandidate genes for male and female reproductive traits in Canchim beef cattle.
dc.typeArtigo de periódico
dc.date.updated2018-02-01T11:11:11Zpt_BR
dc.subject.thesagroGado de corte
dc.subject.thesagroGado Canchim
dc.subject.nalthesaurusBeef cattle
dc.subject.nalthesaurusGenome-wide association study
dc.subject.nalthesaurusSingle nucleotide polymorphism
dc.subject.nalthesaurusQuantitative trait loci
dc.description.notesArtigo 67. Na publicação: Marcos Vinícius Gualberto Barbosa da Silva.
riaa.ainfo.id1074373
riaa.ainfo.lastupdate2018-02-01 -02:00:00
dc.identifier.doi10.1186/s40104-017-0199-8
dc.contributor.institutionMARCOS ELI BUZANSKAS, UFPB
dc.contributor.institutionDANIELA DO AMARAL GROSSI, Fast Genetics, Saskatoonpt_BR
dc.contributor.institutionRICARDO VIEIRA VENTURA, Beef Improvement Opportunities, Guelphpt_BR
dc.contributor.institutionFLAVIO SCHRAMM SCHENKEL, University of Guelphpt_BR
dc.contributor.institutionTATIANE CRISTINA SELEGUIM CHUD, FCAV/Unesppt_BR
dc.contributor.institutionNEDENIA BONVINO STAFUZZA, FCAV/Unesppt_BR
dc.contributor.institutionLUCIANA DINIZ ROLA, FCAV/Unesppt_BR
dc.contributor.institutionSARAH LAGUNA CONCEIÇÃO MEIRELLES, Uflapt_BR
dc.contributor.institutionFABIANA BARICHELLO MOKRY, UFSCarpt_BR
dc.contributor.institutionMAURICIO DE ALVARENGA MUDADU, CNPTIApt_BR
dc.contributor.institutionROBERTO HIROSHI HIGA, CNPTIApt_BR
dc.contributor.institutionMARCOS VINICIUS GUALBERTO B SILVA, CNPGLpt_BR
dc.contributor.institutionMAURICIO MELLO DE ALENCAR, CPPSEpt_BR
dc.contributor.institutionLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSEpt_BR
dc.contributor.institutionDANÍSIO PRADO MUNARI, FCAV/Unesp.pt_BR
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