Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1074725
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorFIDELIS, Q. C.
dc.contributor.authorCASTRO, R. N.
dc.contributor.authorGUILHON, G. M. S. P.
dc.contributor.authorRODRIGUES, S. T.
dc.contributor.authorSALLES, C. M. C. de
dc.contributor.authorSALLES, J. B. de
dc.contributor.authorCARVALHO, M. G. de
dc.date.accessioned2017-09-02T06:18:03Z-
dc.date.available2017-09-02T06:18:03Z-
dc.date.created2017-08-30
dc.date.issued2012
dc.identifier.citationMolecules, v. 17, n. 7, p. 7989-8000, 2012.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1074725pt_BR
dc.descriptionThe chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents.
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectBiflavonoides
dc.subjectIsoflavonas
dc.subjectAgentes quimiopreventivos
dc.titleFlavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.
dc.typeArtigo de periódico
dc.date.updated2017-09-02T06:18:03Zpt_BR
riaa.ainfo.id1074725
riaa.ainfo.lastupdate2017-08-30
dc.contributor.institutionQueli C. Fidelis, Universidade Federal Rural do Rio de Janeiro; Rosane N. Castro, Universidade Federal Rural do Rio de Janeiro; Giselle M. S. P. Guilhon, UFPA; SILVANE TAVARES RODRIGUES, CPATU; Cristiane M. C. de Salles, Universidade Federal Rural do Rio de Janeiro; João B. de Salles, UEZO; Mario G. de Carvalho, Universidade Federal Rural do Rio de Janeiro.
Aparece nas coleções:Artigo em periódico indexado (CPATU)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
molecules1707989.pdf226.27 kBAdobe PDFThumbnail
Visualizar/Abrir
Mostrar registro simples do item Visualizar estatísticas

FacebookTwitterDeliciousLinkedInGoogle BookmarksMySpace