Use este identificador para citar ou linkar para este item:
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1107120Registro completo de metadados
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | MESQUITA, L. M. de S. | eng |
| dc.contributor.author | RODRIGUES, C. F. B. | eng |
| dc.contributor.author | ROCHA, C. Q. da | eng |
| dc.contributor.author | BIANCHIM, M. S. | eng |
| dc.contributor.author | RODRIGUES, C. M. | eng |
| dc.contributor.author | OLIVEIRA, V. de | eng |
| dc.contributor.author | GAETA, H. H. | eng |
| dc.contributor.author | BELCHOR, M. N. | eng |
| dc.contributor.author | TOYAMA. M. H. | eng |
| dc.contributor.author | VILEGAS, W. | eng |
| dc.date.accessioned | 2019-03-15T18:13:00Z | - |
| dc.date.available | 2019-03-15T18:13:00Z | - |
| dc.date.created | 2019-03-15 | |
| dc.date.issued | 2019 | |
| dc.identifier.citation | Natural Products and Bioprospecting, v. 9, p. 23-34, 2019. | eng |
| dc.identifier.uri | http://www.alice.cnptia.embrapa.br/alice/handle/doc/1107120 | - |
| dc.description | We recognize the chemical composition of the acetonic extract of Rhizophora mangle barks (AERM) using mass spectrometry analysis [liquid chromatography (LC)?ESI?IT-MS/MS and matrix-assisted laser desorption/ionization-time of flight-MS (MALDI-TOF)]. Analgesic activity was evaluated by formalin and tail-flick experimental assays. Anti-inflammatory activity was performed by paw edema test induced by carrageenan and 48/80 compounds. The first series of experiments involved [LC]?FIA?IT-MS/MS with 11 separated catechins derivatives until degree of polymerization 3 (DP3). The spectra obtained by MALDI-TOF analysis of the AERM presented two homologous series: one based on polymers of m/z 288 Da increments (up to DP12) and another series based on polymers of m/z [288 ? 162] Da increments (up to DP11). In addition to these series of flavan-3-ol, each DP had a subset of masses with a variation of - 16 Da (homologous series of afzelechins?m/z 873?3465 Da) and ? 16 Da (homologous series of gallocatechins?m/z 905?3497 Da). A similar pattern with homologous series of gallocatechins and afzelechins could also be observed for a fifth and a sixth monohexoside series: glucogallocatechins (m/z 779?3371) and glucoafzelechins (m/z 747?3339). The intraperitoneal administration of different doses of AERM (50, 150 and 300 lg mL-1) have a morphine-like effect and intense anti-inflammatory activity. | eng |
| dc.language.iso | eng | eng |
| dc.rights | openAccess | eng |
| dc.subject | Morphine-like effect | eng |
| dc.subject | Catechins | eng |
| dc.subject | Anti-inflammatory | eng |
| dc.subject | Mangroves | eng |
| dc.title | LC-ESI-IT-MS/MS and MALDI-TOF approach: identification of natural polymers from rhizophora mangle barks and determination of their analgesic and anti-inflammatory properties. | eng |
| dc.type | Artigo de periódico | eng |
| dc.date.updated | 2019-11-18T11:11:11Z | |
| riaa.ainfo.id | 1107120 | eng |
| riaa.ainfo.lastupdate | 2019-11-18 -02:00:00 | eng |
| dc.contributor.institution | Leonardo Mendes de Souza Mesquita; Caroline Fabri Bittencourt Rodrigues; Claudia Quintino da Rocha; Mayara Silveira Bianchim; CLENILSON MARTINS RODRIGUES, CNPAE; Vanda Maria de Oliveira; Henrique Hessel Gaeta; Mariana Novo Belchor; Marcos Hikari Toyama; Wagner Vilegas. | eng |
| Aparece nas coleções: | Artigo em periódico indexado (CNPAE)  | |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| CLENILSON041NaturalProductsandBioprospecting.pdf | 1.1 MB | Adobe PDF |  Visualizar/Abrir |
