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dc.contributor.authorOLIVEIRA, P. S. N. deeng
dc.contributor.authorCOUTINHO, L. L.eng
dc.contributor.authorCESAR, A. S. M.eng
dc.contributor.authorDINIZ, W. J. da S.eng
dc.contributor.authorSOUZA, M. de S.eng
dc.contributor.authorANDRADE, B. G.eng
dc.contributor.authorKOLTES, J. E.eng
dc.contributor.authorMOURÃO, G. B.eng
dc.contributor.authorZERLOTINI NETO, A.eng
dc.contributor.authorREECY, J. M.eng
dc.contributor.authorREGITANO, L. C. de A.eng
dc.date.accessioned2019-07-25T01:02:05Z-
dc.date.available2019-07-25T01:02:05Z-
dc.date.created2019-07-24
dc.date.issued2019
dc.identifier.citationFrontiers in Genetics, v. 10, p. 1-14, July 2019.eng
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1110820-
dc.descriptionFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption.eng
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectÁcido linoleico conjugadoeng
dc.subjectÁcido oleicoeng
dc.subjectÁcidos graxoseng
dc.subjectGenômicaeng
dc.subjectRedes de co-expressãoeng
dc.subjectIntegrative genomicseng
dc.subjectMRNAeng
dc.subjectMiRNAeng
dc.titleCo-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle.eng
dc.typeArtigo de periódicoeng
dc.date.updated2019-10-02T11:11:11Z
dc.subject.thesagroBos Indicuseng
dc.subject.thesagroGado de Corteeng
dc.subject.nalthesaurusBeef cattleeng
dc.subject.nalthesaurusConjugated linoleic acideng
dc.subject.nalthesaurusOleic acideng
dc.description.notesArticle 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.eng
riaa.ainfo.id1110820eng
riaa.ainfo.lastupdate2019-10-02 -03:00:00
dc.identifier.doi10.3389/fgene.2019.00651eng
dc.contributor.institutionPRISCILA S. N. DE OLIVEIRA, CPPSE; LUIZ L. COUTINHO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP; WELLISON J. DA SILVA DINIZ, UFSCar; MARCELA M. DE SOUZA, Iowa State University; BRUNO G. ANDRADE, CPPSE; JAMES E. KOLTES, Iowa State University; GERSON B. MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.eng
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