Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1119316
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dc.contributor.authorCASTRO, C. B. DE
dc.contributor.authorLUZ, L. DOS R.
dc.contributor.authorGUEDES, J. A. C.
dc.contributor.authorPORTO, D. D.
dc.contributor.authorSILVA, M. F. S.
dc.contributor.authorSILVA, G. S. DA
dc.contributor.authorRIBEIRO, P. R. V.
dc.contributor.authorCANUTO, K. M.
dc.contributor.authorBRITO, E. S. de
dc.contributor.authorZAMPIERI, D. DE S.
dc.contributor.authorPESSOA, C. do Ó.
dc.contributor.authorZOCOLO, G. J.
dc.date.accessioned2023-01-13T10:01:20Z-
dc.date.available2023-01-13T10:01:20Z-
dc.date.created2020-01-24
dc.date.issued2020
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 31, n. p. 775-787, 2020.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1119316-
dc.descriptionMyracrodruon urundeuva (aroeira-do-sertão) is a species threatened with extinction due to anthropogenic exploitation. Phytochemical analysis of bark, branch and leaf extracts revealed the presence of several compounds such as flavonoids, phenols, tannins, quercetin derivatives and anacardic acids. Dereplication methodology was performed to tentatively identify 50 compounds analyzed by ultra-performance liquid chromatography coupled with an electrospray ionization quadrupole time-of-flight mass spectrometry operating in MSE mode (UPLC-QTOF-MSE). The extracts exhibited anti-tumor effect in cancer cells HCT-116 (colorectal), SF-295 (glioblastoma), HL-60 (leukemia), and RAJI (leukemia). Also, these results correlate with the principal component analysis (PCA) data that identified three distinct groups indicating, efficiently, metabolic differences between organs of M. urundeuva. Through discriminatory analysis of the orthogonal partial least squares (OPLS-DA), the variable of importance in the projection (VIP) and S-Plot, we were able to determine 30 potential biomarkers. The fingerprint of hydroethanolic extracts was correlated with the cytotoxicity assay and demonstrated a significant difference in the composition of plant extract.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectUPLC-MS/MS
dc.subjectQuimiometria
dc.subjectAtividade citotóxica
dc.subjectAroeira do sertão
dc.subjectBioma Caatinga
dc.titleMetabolomics-based discovery of biomarkers with cytotoxic potential in extracts of Myracrodruon urundeuva.
dc.typeArtigo de periódico
dc.subject.thesagroMyracrodruon Urundeuva
dc.subject.thesagroAroeira
dc.subject.thesagroCaatinga
dc.subject.thesagroEspécie Nativa
dc.subject.thesagroVegetação Nativa
dc.subject.nalthesaurusChemometrics
dc.subject.nalthesaurusCytotoxicity
riaa.ainfo.id1119316
riaa.ainfo.lastupdate2023-01-12
dc.identifier.doihttp://dx.doi.org/10.21577/0103-5053.20190242
dc.contributor.institutionCAIO BEZERRA DE CASTRO, Universidade Federal de São Carlos. Departamento de Química; LICIA DOS REIS LUZ, Universidade Federal do Ceará. Departamento de Química Analítica e Físico-Química.; JHONYSON ARRUDA CARVALHO GUEDES, CNPAT; DIOGO DENARDI PORTO, CPATSA; MARIA FRANCILENE SOUZA SILVA, Universidade Federal do Ceará. Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM); GISELE SILVESTRE DA SILVA, CNPAT; PAULO RICELI VASCONCELOS RIBEIRO, CNPAT; KIRLEY MARQUES CANUTO, CNPAT; EDY SOUSA DE BRITO, CNPAT; DÁVILA DE SOUZA ZAMPIERI, Universidade Federal do Ceará. Departamento de Química Orgânica e Inorgânica.; ClLAUDIA DO Ó PESSOA, Universidade Federal do Ceará. Núcleo de Pesquisa e Desenvolvimento de Medicamentos (NPDM).; GUILHERME JULIAO ZOCOLO, CNPAT.
Appears in Collections:Artigo em periódico indexado (CPATSA)

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