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dc.contributor.authorDEFANT, H.eng
dc.contributor.authorMEIRA, A. N.eng
dc.contributor.authorCOUTINHO, L. L.eng
dc.contributor.authorREGITANO, L. C. de A.eng
dc.contributor.authorPOLETI, M. D.eng
dc.contributor.authorMOREIRA, G. C. M.eng
dc.contributor.authorPADUAN, M.eng
dc.contributor.authorMARIANI, P.eng
dc.contributor.authorZERLOTINI NETO, A.eng
dc.contributor.authorMOURÃO, G. B.eng
dc.contributor.authorCESAR, A. S. M.eng
dc.date.accessioned2020-01-28T18:11:29Z-
dc.date.available2020-01-28T18:11:29Z-
dc.date.created2020-01-28
dc.date.issued2019
dc.identifier.citationGenetics and Molecular Research, v. 18, n. 3, 2019.eng
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1119464-
dc.descriptionABSTRACT. Genetic variations in genes involved in lipid storage, which also may interfere with important phenotypic traits such as intramuscular fat deposition in cattle, can represent useful markers in marker assisted selection programs. An important candidate gene is perilipin 2 (PLIN2) that plays a role in the capture of long chain fatty acids and in the formation and stabilization of lipid droplets in different tissues including muscle. As reported by our group, PLIN2 expression level was associated with trans-eQTL (expression quantitative loci distant of gene associated) at chr3: 87, 253, 086 in Nellore cattle, where animals with different genotypes showed different expression level of PLIN2 among the 193 animals and the co-expression analysis detected correlation with intramuscular fat, palmitoleic, oleic and linoleic acids. Then, the objective of this study was to identify and characterize polymorphisms present in the PLIN2 gene of Nellore cattle. To date, there is not much information on mutations in the PLIN2 gene in Bos indicus animals. A total of 134 single nucleotide polymorphisms (SNPs) were identified in the genomic region of PLIN2 gene and five of those are novel with a moderate impact. These SNPs may change the protein effectiveness and, after further association studies and functional validation, could be used as genomic markers in animal breeding program.eng
dc.language.isoengeng
dc.rightsopenAccesseng
dc.subjectPerilipin 2eng
dc.subjectPLIN2eng
dc.subjectPolimorfismo de nucleotídeo únicoeng
dc.subjectSNPeng
dc.subjectProcessos biológicoseng
dc.subjectGordura intramusculareng
dc.subjectGota lipídicaeng
dc.subjectExpressão gênicaeng
dc.subjectBiological processeng
dc.subjectLipid dropleteng
dc.subjectVariantseng
dc.titleNovel polymorphisms in the PLIN2 gene of Nellore cattle.eng
dc.typeArtigo de periódicoeng
dc.date.updated2020-04-20T11:11:11Z
dc.subject.thesagroGadoeng
dc.subject.thesagroBos Indicuseng
dc.subject.nalthesaurusNelloreeng
dc.subject.nalthesaurusCattleeng
dc.subject.nalthesaurusSingle nucleotide polymorphismeng
dc.subject.nalthesaurusGene expressioneng
dc.subject.nalthesaurusIntramuscular fateng
dc.description.notesNa publicação: Luciana CA Regitano, Adhemar Zerlotini. gmr16039963.eng
dc.format.extent2Não paginado.eng
riaa.ainfo.id1119464eng
riaa.ainfo.lastupdate2020-04-20 -03:00:00
dc.contributor.institutionHELOISA DEFANT, Esalq/USP; ARIANA N. MEIRA, Esalq/USP; LUIZ L. COUTINHO, Esalq/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; MIRELE D. POLETI, USP; GABRIEL C. M. MOREIRA, Esalq/USP; MARCELA PADUAN, Esalq/USP; PILAR MARIANI, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; GERSON B. MOURÃO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP.eng
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