Por favor, use este identificador para citar o enlazar este ítem: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1121033
Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorSIMAS, P. V. M
dc.contributor.authorBASSETTO, C. C.
dc.contributor.authorGIGLIOTI, R.
dc.contributor.authorOKINO, C. H.
dc.contributor.authorOLIVEIRA, H. N. de
dc.contributor.authorOLIVEIRA, M. C. de S.
dc.date.accessioned2020-03-13T15:58:58Z-
dc.date.available2020-03-13T15:58:58Z-
dc.date.created2020-03-09
dc.date.issued2020
dc.identifier.citationInfection, Genetics and Evolution, v. 79, 2020. 104161.
dc.identifier.issn1567-1348
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1121033-
dc.descriptionCattle babesiosis is a tick-borne disease responsible for significant losses for the livestock industries in tropical areas of the world. These piroplasms are under constant control of the host immune system, which lead to a strong selective pressure for arising more virulent or attenuated phenotypes. Aiming to better understand the most critical genetic modifications in Babesia bovis genome, related to virulence, an in silico analysis was performed using DNA sequences from GenBank. Fourteen genes (sbp-2, sbp-4, trap, msa-1, msa-2b, msa-2c, Bv80 (or Bb-1), 18S rRNA, acs-1, ama-1, ?-tub, cp-2, p0, rap-1a) related to parasite infection and immunogenicity and ITS region were selected for alignment and comparison of several isolates of Babesia bovis from different geographic regions around the world. Among the 15 genes selected for the study of diversity, only 7 genes (sbp-2, sbp-4, trap, msa-1, msa-2b, msa-2c, Bv80) and the ITS region presented sufficient genetic variation for the studies of phylogeny. Despite this genetic diversity observed into groups, there was not sufficient information available to associate molecular markers with virulence of isolates. However, some genetic groups no were correlated with geographic region what could indicate some typical evolutionary characteristics in the relation between parasite-host. Further studies using these genes in herds presenting diverse clinical conditions are required. The better understanding of evolutionary mechanisms of the parasite may contribute to improve prophylactic and therapeutic measures. In this way, we suggest that genes used in our study are potential markers of virulence and attenuation and have to be analyzed with the use of sequences from animals that present clinical signs of babesiosis and asymptomatic carriers.
dc.language.isoeng
dc.rightsopenAccesseng
dc.subjectMolecular markers
dc.subjectGenetic diversity
dc.subjectAttenuation
dc.titleUse of molecular markers can help to understand the genetic diversity of Babesia bovis.
dc.typeArtigo de periódico
dc.date.updated2020-04-20T11:11:11Z
dc.subject.thesagroBabesia Bovis
dc.subject.nalthesaurusVirulence
dc.format.extent29
riaa.ainfo.id1121033
riaa.ainfo.lastupdate2020-04-20 -03:00:00
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2019.104161
dc.contributor.institutionPaulo Vitor Marques Simas, UNESP; César Cristiano Bassetto, UNESP; Rodrigo Giglioti, Instituto de Zootecnia; CINTIA HIROMI OKINO, CPPSE; Henrique Nunes de Oliveira, UNESP; MARCIA CRISTINA DE SENA OLIVEIRA, CPPSE.
Aparece en las colecciones:Artigo em periódico indexado (CPPSE)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Use-of-molecular-markers-can-help-to-understand-the-2020-Infection-Genetics.pdf2.96 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro sencillo del ítem

FacebookTwitterDeliciousLinkedInGoogle BookmarksMySpace