Title:	Safety and effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on inflammation and tissue repair of oral wounds in rats.
Authors:	ALVARENGA, M. O. P. BITTENCOURT, L. O. MENDES, P. F. S. RIBEIRA, J. T. LAMEIRA, O. A. MONTEIRO, M. C. BARBOZA, C. A. G. MARTINS, M. D. LIMA, R. R.
Affiliation:	María Olimpia Paz Alvarenga, UFPA; Leonardo Oliveira Bittencourt, UFPA; Paulo Fernando Santos Mendes, UFPA; Julia Turra Ribeiro, UFRGS; OSMAR ALVES LAMEIRA, CPATU; Marta Chagas Monteiro, UFPA; Carlos Augusto Galvão Barboza, UFRGS; Manoela Domingues Martins, UFRGS; Rafael Rodrigues Lima, UFPA.
Date Issued:	2020
Citation:	International Journal of Molecular Science, v. 21, n. 10, article 3568, 2020.
Description:	In traditional communities of the Brazilian Amazon, the copaiba oleoresin (C. reticulata Ducke) is widely known for its therapeutic activity, especially its wound healing and anti-inflammatory actions. Our study aimed to evaluate these effects in oral lesions and the safety of the dosage proposed. A punch biopsy wound was induced on the ventral surface of the tongue of forty-five male Wistar rats under anesthesia. Animals were randomly allocated to one of three groups based on the treatment: control, corticoid and copaiba. A daily dose of each treatment and vehicle was administrated by oral gavage for three consecutive days. Sample collections took place on the third, seventh and 15th days post-wounding for clinical and histopathological analyses. Blood was collected on the third and seventh days for kidneys and liver function tests. Semi-quantitative analyses were performed based on scores of inflammation and reepithelization. Tissue collagen deposition was detected by PicroSirius red staining. Copaiba-treated wounds revealed a smaller wound area, decreased of acute inflammatory reaction and enhanced reepithelization. The levels of kidney and liver function tests did not reveal presence of damage post-treatments. Our findings suggest that copaiba oleoresin is a safe and effective alternative therapy for inflammation and tissue repair of oral wounds in this animal model.
Thesagro:	Copaíba Antiinflamatório Terapia Oleorresina Cicatrização
DOI:	https://doi.org/10.3390/ijms21103568
Type of Material:	Artigo de periódico
Access:	openAccess
Appears in Collections:	Artigo em periódico indexado (CPATU)