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dc.contributor.authorROBERTS, A.
dc.contributor.authorBOECKMAN, C. J.
dc.contributor.authorMÜHL, M.
dc.contributor.authorROMEIS, J.
dc.contributor.authorTEEM, J. L.
dc.contributor.authorVALICENTE, F. H.
dc.contributor.authorBROWN, J. K.
dc.contributor.authorEDWARDS, M. G.
dc.contributor.authorLEVINE, S. L.
dc.contributor.authorMELNICK, R. L.
dc.contributor.authorROFRIGUES, T. B.
dc.contributor.authorVÉLEZ, A. M.
dc.contributor.authorZHOU, X.
dc.contributor.authorHELLMICH, R. L.
dc.date.accessioned2020-07-01T11:10:59Z-
dc.date.available2020-07-01T11:10:59Z-
dc.date.created2020-06-30
dc.date.issued2020
dc.identifier.citationFrontiers in Bioengineering and Biotechnology, v. 8, article 556, 2020.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1123519-
dc.descriptionHistorically, genetically engineered (GE) plants that have incorporated genes conferring insect protection have primarily used Cry proteins derived from Bacillus thuringiensis (Bt) to achieve their insecticidal phenotype. As a result, regulators have developed a level of familiarity and confidence in reviewing plants incorporating these insecticidal proteins. However, new technologies have been developed that produce GE plants that incorporate pest protection by triggering an RNA interference (RNAi) response or proteins other than Bt Cry proteins. These technologies have new modes of action. Although the overall assessment paradigm for GE plants is robust, there are ongoing discussions about the appropriate tests and measurement endpoints needed to inform non-target arthropod assessment for technologies that have a different mode of action than the Bt Cry proteins. As a result, increasing attention is being paid to the use of sublethal endpoints and their value for environmental risk assessment (ERA). This review focuses on the current status and history of sublethal endpoint use in insect-active GE crops, and evaluates the future use of sublethal endpoints for new and emerging technologies. It builds upon presentations made at the Workshop on Sublethal Endpoints for Non-target Organism Testing for Non-Bt GE Crops (Washington DC, USA, 4â??5 March 2019), and the discussions of government, academic and industry scientists convened for the purpose of reviewing the progress and status of sublethal endpoint testing in non-target organisms.
dc.language.isoeng
dc.rightsopenAccesseng
dc.subjectOrganismos não-alvo
dc.subjectParâmetros subletais
dc.subjectPlanta geneticamente modificada
dc.titleSublethal endpoints in non-target organism testing for insect-active GE crops.
dc.typeArtigo de periódico
dc.subject.thesagroMelhoramento Genético Vegetal
dc.subject.thesagroControle Biológico
dc.subject.thesagroInseto
dc.subject.thesagroPlanta Transgênica
riaa.ainfo.id1123519
riaa.ainfo.lastupdate2020-06-30
dc.identifier.doihttps://doi.org/10.3389/fbioe.2020.00556
dc.contributor.institutionAndrew Roberts, Agriculture and Food Systems Institute, Washington, DC
dc.contributor.institutionChad J. Boeckman, Corteva Agriscienceeng
dc.contributor.institutionMarina Mühl, Ministerio de Agricultura, Ganadería y Pesca, Dirección de Biotecnología, Buenos Aireseng
dc.contributor.institutionJörg Romeis, Research Division Agroecology and Environment, Agroscope, Zuricheng
dc.contributor.institutionJohn L. Teem, Agriculture and Food Systems Institute, Washington, DCeng
dc.contributor.institutionFERNANDO HERCOS VALICENTE, CNPMSeng
dc.contributor.institutionJudith K. Brown, School of Plant Sciences, The University of Arizona, Tucsoneng
dc.contributor.institutionMartin G. Edwards, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyneeng
dc.contributor.institutionSteven L. Levine, Bayer Crop Science, Chesterfield, MOeng
dc.contributor.institutionRachel L. Melnick, Agriculture and Food Systems Institute, Washington, DCeng
dc.contributor.institutionThais B. Rodrigues, Greenlight Biosciences, Inc., Medford, MAeng
dc.contributor.institutionAna M. Vélez, Department of Entomology, University of Nebraska-Lincolneng
dc.contributor.institutionXuguo Zhou, Department of Entomology, University of Kentucky, Lexington, KYeng
dc.contributor.institutionRichard L. Hellmich, USDA, Corn Insects and Crop Genetics Research Unit, Ames.eng
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