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dc.contributor.authorMEDEIROS, A. M. Z.
dc.contributor.authorKHAN, L. U.
dc.contributor.authorSILVA, G. H. da
dc.contributor.authorOSPINA, C. A.
dc.contributor.authorALVES, O. L.
dc.contributor.authorCASTRO, V. L. S. S. de
dc.contributor.authorMARTINEZ, D. S. T.
dc.date.accessioned2021-04-05T15:33:57Z-
dc.date.available2021-04-05T15:33:57Z-
dc.date.created2021-04-05
dc.date.issued2021
dc.identifier.citationEcotoxicology and Environmental Safety, v. 209, article 111776, 2021.
dc.identifier.issn0147-6513
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1131052-
dc.descriptionAbstract: This work reports an integrated nanosafety study including the synthesis and characterization of the graphene oxide-silver nanoparticle hybrid material (GO-AgNPs) and its nano-ecotoxicity evaluation in the zebrafish embryo model. The influences of natural organic matter (NOM) and a chorion embryo membrane were considered in this study, looking towards more environmentally realistic scenarios and standardized nanotoxicity testing. The nanohybrid was successfully synthesized using the NaBH4 aqueous method, and AgNPs (~ 5.8 nm) were evenly distributed over the GO surface. GO-AgNPs showed a dose-response acute toxicity: the LC50 was 1.5 mg L-1 for chorionated embryos. The removal of chorion, however, increased this toxic effect by 50%. Furthermore, the presence of NOM mitigated mortality, and LC50 for GO-AgNPs changed respectively from 2.3 to 1.2 mg L-1 for chorionated and de-chorionated embryos. Raman spectroscopy confirmed the ingestion of GO by embryos; but without displaying acute toxicity up to 100 mg L-1, indicating that the silver drove toxicity down. Additionally, it was observed that silver nanoparticle dissolution has a minimal effect on these observed toxicity results. Finally, understanding the influence of chorion membranes and NOM is a critical step towards the standardization of testing for zebrafish embryo toxicity in safety assessments and regulatory issues.
dc.language.isoeng
dc.rightsopenAccesseng
dc.subjectNanohybrids
dc.subjectNanoecotoxicology
dc.subjectNanotoxicity
dc.subjectAlternative methods
dc.subjectGrafeno
dc.subjectNanomateriais
dc.titleGraphene oxide-silver nanoparticle hybrid material: an integrated nanosafety study in zebrafish embryos.
dc.typeArtigo de periódico
dc.subject.thesagroComposto de Carbono
dc.subject.thesagroToxidez
dc.subject.thesagroPeixe de Água Doce
dc.subject.nalthesaurusEcotoxicology
dc.subject.nalthesaurusGraphene oxide
dc.subject.nalthesaurusNanomaterials
dc.subject.nalthesaurusDanio rerio
dc.subject.nalthesauruschorioneng
riaa.ainfo.id1131052
riaa.ainfo.lastupdate2021-04-05
dc.identifier.doihttps://doi.org/10.1016/j.ecoenv.2020.111776
dc.contributor.institutionALINE MARIA ZIGIOTTO DE MEDEIROS, CNPEM; LATIF ULLAH KHAN, CNPEM; GABRIELA HELENA DA SILVA, CNPEM; CARLOS ALBERTO OSPINA, CNPEM; OSWALDO LUIZ ALVES, IQ-UNICAMP; VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; DIEGO STÉFANI TEODORO MARTINEZ, CNPEM.
Aparece en las colecciones:Artigo em periódico indexado (CNPMA)

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