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dc.contributor.authorVIEIRA, L. R.
dc.contributor.authorFREITAS, N. C.
dc.contributor.authorJUSTEN, F.
dc.contributor.authorMIRANDA, V. de J.
dc.contributor.authorGARCIA, B. de O.
dc.contributor.authorNEPOMUCENO, A. L.
dc.contributor.authorFUGANTI-PAGLIARINI, R.
dc.contributor.authorFELIPE, M. S. S.
dc.contributor.authorMOLINARI, H. B. C.
dc.contributor.authorVELINI, E. D.
dc.contributor.authorPINTO, E. R. de C.
dc.contributor.authorDAGLI, M. L. Z.
dc.contributor.authorANDRADE, G.
dc.contributor.authorFERNANDES, P. M. B.
dc.contributor.authorMERTZ-HENNING, L. M.
dc.contributor.authorKOBAYASHI, A. K.
dc.date.accessioned2021-06-02T19:18:26Z-
dc.date.available2021-06-02T19:18:26Z-
dc.date.created2021-06-02
dc.date.issued2021
dc.identifier.citationIn: MOLINARI, H. B. C.; VIEIRA, L. R.; SILVA, N. V. e; PRADO, G. S.; LOPES FILHO, J. F. (Ed.). CRISPR technology in plant genome editing: biotechnology applied to agriculture. Brasília, DF : Embrapa, 2021. Chapter 5, p. 169-195.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1132164-
dc.descriptionThe regulation of the use of products obtained through genome-editing techniques has been the subject of great debate worldwide. Currently, the discussions are mainly focused on whether products obtained by different strategies of site-directed nucleases (SDN) should or not be classified as Genetically Modified Organisms (GMOs). In the SDN-1 application, the natural DNA cell repair pathway (Non-Homologous End-Joining - NHEJ) is explored to introduce simple random mutations (substitutions, insertions, and deletions) by systems such as CRISPR-Cas, TALENs, or Zinc Fingers Nucleases, which cause silencing of the gene product after breaking DNA (by Double-Strand Break - DSB). In the SDN-2 approach, a template DNA is also used to introduce a change in the sequence of nitrogen bases (A, C, G, T) at the target site where the DSB occurred, exploring another natural repair system directed by a DNA fragment from the same species (Homology-Directed Repair - HDR). In the SDN-3 approach, both NHEJ and HDR can be explored to insert one or more DNA fragments with sequences necessary for the expression of a gene (promoter, coding, and terminator region) at a specific location in the genome. In the following topics, questions related to genome editing regulation in different countries are discussed in detail.
dc.language.isoeng
dc.rightsopenAccesseng
dc.titleRegulatory framework of genome editing in Brazil and worldwide.
dc.typeParte de livro
dc.subject.thesagroBiotecnologia
dc.subject.thesagroDNA
dc.subject.thesagroEngenharia Genética
dc.subject.thesagroGenética Vegetal
dc.subject.thesagroLegislação
dc.subject.nalthesaurusBiotechnology
dc.subject.nalthesaurusGenetic engineering
dc.subject.nalthesaurusGenetically modified organisms
dc.subject.nalthesaurusPlant genetics
riaa.ainfo.id1132164
riaa.ainfo.lastupdate2021-06-02
dc.contributor.institutionLETÍCIA RIOS VIEIRA; NATÁLIA CHAGAS FREITAS; FERNANDA JUSTEN; VÍVIAN DE JESUS MIRANDA; BRUNO DE OLIVEIRA GARCIA, Universidade Federal de Lavras; ALEXANDRE LIMA NEPOMUCENO, CNPSO; RENATA FUGANTI-PAGLIARINI; MARIA SUELI SOARES FELIPE, Universidade Católica de Brasília; HUGO BRUNO CORREA MOLINARI, CNPAE; EDIVALDO DOMINGUES VELINI, Universidade Estadual Paulista; EDUARDO ROMANO DE CAMPOS PINTO, Cenargen; MARIA LUCIA ZAIDAN DAGLI, Universidade de São Paulo; GALDINO ANDRADE, Universidade Estatual de Londrina; PATRICIA MACHADO BUENO FERNANDES, Universidade Federal do Espírito Santo; LILIANE MARCIA MERTZ HENNING, CNPSO; ADILSON KENJI KOBAYASHI, CNPAE.
Aparece nas coleções:Capítulo em livro científico (CNPSO)

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