Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1133730
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dc.contributor.authorVERARDO, L. L.eng
dc.contributor.authorSILVA, F. F. eeng
dc.contributor.authorMACHADO, M. A.eng
dc.contributor.authorPANETTO, J. C. do C.eng
dc.contributor.authorREIS, D. R. de L.eng
dc.contributor.authorOTTO, P. I.eng
dc.contributor.authorREGITANO, L. C. de A.eng
dc.contributor.authorSILVA, L. O. C. daeng
dc.contributor.authorEGITO, A. A. doeng
dc.contributor.authorALBUQUERQUE, M. do S. M.eng
dc.contributor.authorZANELLA, R.eng
dc.contributor.authorSILVA, M. V. G. B.eng
dc.date.accessioned2021-08-19T14:01:00Z-
dc.date.available2021-08-19T14:01:00Z-
dc.date.created2021-08-19
dc.date.issued2021
dc.identifier.citationFrontiers in Genetics, v. 12, article 702822, 2021.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1133730-
dc.descriptionCattle population history, breeding systems, and geographic subdivision may be reflected in runs of homozygosity (ROH), effective population size (Ne), and linkage disequilibrium (LD) patterns. Thus, the assessment of this information has become essential to the implementation of genomic selection on purebred and crossbred cattle breeding programs. In this way, we assessed the genotype of 19 cattle breeds raised in Brazil belonging to taurine, indicine, synthetic crossbreds, and Iberian-derived locally adapted ancestries to evaluate the overall LD decay patterns, Ne, ROH, and breed composition. We were able to obtain a general overview of the genomic architecture of cattle breeds currently raised in Brazil and other tropical countries. We found that, among the evaluated breeds, different marker densities should be used to improve the genomic prediction accuracy and power of genome-wide association studies. Breeds showing low Ne values indicate a recent inbreeding, also reflected by the occurrence of longer ROH, which demand special attention in the matting schemes to avoid extensive inbreeding. Candidate genes (e.g., ABCA7, PENK, SPP1, IFNAR1, IFNAR2, SPEF2, PRLR, LRRTM1, and LRRTM4) located in the identified ROH islands were evaluated, highlighting biological processes involved with milk production, behavior, rusticity, and fertility. Furthermore, we were successful in obtaining the breed composition regarding the taurine and indicine composition using single-nucleotide polymorphism (SNP) data.
dc.language.isoeng
dc.rightsopenAccesseng
dc.subjectRusticidade
dc.subjectRusticity
dc.titleGenome-wide analyses reveal the genetic architecture and candidate genes of indicine, taurine, synthetic crossbreds, and locally adapted cattle in Brazil.
dc.typeArtigo de periódico
dc.subject.thesagroBovino
dc.subject.thesagroGado
dc.subject.thesagroGenética Animal
dc.subject.thesagroGenoma
dc.subject.thesagroProdução Leiteira
dc.subject.thesagroComportamento Animal
dc.subject.thesagroFertilidade Animal
dc.subject.nalthesaurusHomozygosity
dc.subject.nalthesaurusPopulation size
dc.subject.nalthesaurusLinkage disequilibrium
dc.subject.nalthesaurusMilk production
dc.subject.nalthesaurusAnimal behavior
dc.subject.nalthesaurusAnimal fertility
riaa.ainfo.id1133730
riaa.ainfo.lastupdate2021-08-19
dc.identifier.doihttps://doi.org/10.3389/fgene.2021.702822
dc.contributor.institutionLUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionFABYANO FONSECA E SILVA, Universidade Federal de Viçosaeng
dc.contributor.institutionMARCO ANTONIO MACHADO, CNPGLeng
dc.contributor.institutionJOAO CLAUDIO DO CARMO PANETTO, CNPGLeng
dc.contributor.institutionDANIELE RIBEIRO DE LIMA REIS FAZA, CNPGLeng
dc.contributor.institutionPAMELA ITAJARA OTTO, Universidade Federal de Santa Mariaeng
dc.contributor.institutionLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSEeng
dc.contributor.institutionLUIZ OTAVIO CAMPOS DA SILVA, CNPGCeng
dc.contributor.institutionANDREA ALVES DO EGITO, CNPGCeng
dc.contributor.institutionMARIA DO SOCORRO MAUÉS ALBUQUERQUEeng
dc.contributor.institutionRICARDO ZANELLA, Universidade de Passo Fundoeng
dc.contributor.institutionMARCOS VINICIUS GUALBERTO B SILVA, CNPGL.eng
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