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dc.contributor.authorOLIVEIRA, E. R.
dc.contributor.authorFAYER, L.
dc.contributor.authorZANETTE, R. S. S.
dc.contributor.authorLADEIRA, L. O.
dc.contributor.authorOLIVEIRA, L. F. C. de
dc.contributor.authorMARANDUBA, C. M. C.
dc.contributor.authorBRANDAO, H. de M.
dc.contributor.authorMUNK, M.
dc.date.accessioned2023-10-04T10:23:55Z-
dc.date.available2023-10-04T10:23:55Z-
dc.date.created2021-10-30
dc.date.issued2022
dc.identifier.citationNanotechnology, v. 33, n. 6, 065101, 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1135728-
dc.descriptionCarboxylated Multi-wall Carbon Nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNTCOOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectNanotecnologia
dc.subjectEstudo in vitro
dc.subjectEngenharia de tecido
dc.subjectCélulas-tronco
dc.titleCytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth.
dc.typeArtigo de periódico
dc.subject.thesagroCarbono
riaa.ainfo.id1135728
riaa.ainfo.lastupdate2023-10-03
dc.identifier.doihttps://doi.org/10.1088/1361-6528/ac335b
dc.contributor.institutionEDUARDA R. OLIVEIRA, Universidade Federal de Juiz de Fora; LEONARA FAYER, Universidade Federal de Juiz de Fora; RAFAELLA S. S. ZANETTE, Universidade Federal de Juiz de Fora; LUIZ O. LADEIRA, Universidade Federal de Minas Gerais; LUIZ F. C. DE OLIVEIRA, Universidade Federal de Juiz de Fora; CARLOS M. C. MARANDUBA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora.
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