Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1137199
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dc.contributor.authorPIZAURO, L. J. L.
dc.contributor.authorALMEIDA, C. C. DE
dc.contributor.authorSILVA, S. R.
dc.contributor.authorMACINNES, J. I.
dc.contributor.authorKROPINSKI, A. M.
dc.contributor.authorZAFALON, L. F.
dc.contributor.authorAVILA, F. A. DE
dc.contributor.authorVARANI, A. DE M.
dc.date.accessioned2021-12-07T12:01:03Z-
dc.date.available2021-12-07T12:01:03Z-
dc.date.created2021-12-07
dc.date.issued2021
dc.identifier.citationScientific Reports, v.11, 2021, 17392.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1137199-
dc.descriptionMastitis is a common and costly disease on dairy farms, commonly caused by Staphylococcus spp. though the various species are associated with different clinical outcomes. In the current study, we performed genomic analyses to determine the prevalence of adhesion, biofilm, and related regulatory genes in 478 staphylococcal species isolated from clinical and subclinical mastitis cases deposited in public databases. The most prevalent adhesin genes (ebpS, atl, pls, sasH and sasF) were found in both clinical and subclinical isolates. However, the ebpS gene was absent in subclinical isolates of Staphylococcus arlettae, S. succinus, S. sciuri, S. equorun, S. galinarum, and S. saprophyticus. In contrast, the coa, eap, emp, efb, and vWbp genes were present more frequently in clinical (vs. subclincal) mastitis isolates and were highly correlated with the presence of the biofim operon (icaABCD) and its transcriptional regulator, icaR. Co-phylogenetic analyses suggested that many of these adhesins, biofilm, and associated regulatory genes could have been horizontally disseminated between clinical and subclinical isolates. Our results further suggest that several adhesins, biofilm, and related regulatory genes, which have been overlooked in previous studies, may be of use for virulence profiling of mastitis-related Staphylococcus strains or as potential targets for vaccine development.
dc.language.isoeng
dc.rightsopenAccesseng
dc.subjectBiofim operon
dc.subjectIcaABCD
dc.subjectIcaR
dc.subjectRegulatory genes
dc.titleGenomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, bioflm, and related regulatory genes.
dc.typeArtigo de periódico
dc.subject.nalthesaurusMastitis
dc.subject.nalthesaurusStaphylococcus
dc.subject.nalthesaurusStaphylococcus arlettae
dc.subject.nalthesaurusStaphylococcus succinus
dc.subject.nalthesaurusStaphylococcus sciuri
dc.subject.nalthesaurusStaphylococcus equorum
dc.subject.nalthesaurusStaphylococcus gallinarum
dc.subject.nalthesaurusStaphylococcus saprophyticus
dc.subject.nalthesaurusAdhesins
dc.subject.nalthesaurusVaccine development
dc.format.extent210 p.
riaa.ainfo.id1137199
riaa.ainfo.lastupdate2021-12-07
dc.identifier.doihttps://doi.org/10.1038/s41598-021-96842-2
dc.contributor.institutionLUCAS JOSÉ LUDUVERIO PIZAURO, UNESP; CAMILA CHIODA DE ALMEIDA, UNESP; SAURA RODRIGUES SILVA, UNESP; JANET I. MACINNES, UNIVERSITY OF GUELPH; ANDREW M. KROPINSKI, UNIVERSITY OF GUELPH; LUIZ FRANCISCO ZAFALON, CPPSE; FERNANDO ANTÔNIO DE AVILA, UNESP; ALESSANDRO DE MELLO VARANI, UNESP.
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