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dc.contributor.authorTIJJANI, A.
dc.contributor.authorSALIM, B.
dc.contributor.authorSILVA, M. V. G. B.
dc.contributor.authorELTAHIR, H. A.
dc.contributor.authorMUSA, T. H.
dc.contributor.authorMARSHALL, K.
dc.contributor.authorHANOTTE, O.
dc.contributor.authorMUSA, H. H.
dc.date.accessioned2022-07-21T16:19:50Z-
dc.date.available2022-07-21T16:19:50Z-
dc.date.created2022-07-21
dc.date.issued2022
dc.identifier.citationGenomics, v. 114, 110423, 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1144851-
dc.descriptionBackground - Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. Results - We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Conclusions - Our results suggest that environmental adaptation may involve recent and ancient selection at generich regions, which might be under a common regulatory genetic control, in zebu cattle.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectAdaptação ao deserto
dc.subjectZebu africano
dc.subjectZebu sudanês
dc.titleGenomic signatures for drylands adaptation at gene-rich regions in African zebu cattle.
dc.typeArtigo de periódico
dc.subject.thesagroGado Zebu
dc.subject.thesagroInsulina
dc.subject.thesagroMetabolismo Animal
riaa.ainfo.id1144851
riaa.ainfo.lastupdate2022-07-21
dc.identifier.doihttps://doi.org/10.1016/j.ygeno.2022.110423
dc.contributor.institutionABDULFATAI TIJJANI, International Livestock Research Institute - ILRI; BASHIR SALIM, University of Khartoum; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; HAMZA A. ELTAHIR, University of Nyala; TAHA H. MUSA, Darfur College; KAREN MARSHALL, International Livestock Research Institute - ILRI; OLIVIER HANOTTE, International Livestock Research Institute - ILRI; HASSAN H. MUSA, University of Nyala.
Aparece en las colecciones:Artigo em periódico indexado (CNPGL)

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