Use este identificador para citar ou linkar para este item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1144893
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dc.contributor.authorSANTOS, C. G. doseng
dc.contributor.authorSOUSA, M. F.eng
dc.contributor.authorVIEIRA, J. I. G.eng
dc.contributor.authorMORAIS, L. R. deeng
dc.contributor.authorFERNANDES, A. A. S.eng
dc.contributor.authorLITTIERE, T. de O.eng
dc.contributor.authorOTTO, P. I.eng
dc.contributor.authorMACHADO, M. A.eng
dc.contributor.authorSILVA, M. V. G. B.eng
dc.contributor.authorBONAFÉ, C. M.eng
dc.contributor.authorMAGALHÃES, A. F. B.eng
dc.contributor.authorVERARDO, L. L.eng
dc.date.accessioned2022-07-25T13:20:05Z-
dc.date.available2022-07-25T13:20:05Z-
dc.date.created2022-07-25
dc.date.issued2022
dc.identifier.citationJournal of Applied Animal Research, v. 50, n. 1, p. 460-470, 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1144893-
dc.descriptionRhipicephalus microplus causes huge losses in cattle. Host genetic background greatly affects the immune efficiency in resistance or susceptibility to tick infestation, which is one of the many factors that play a role on that trait. We performed a systematic review of genome-wide association studies (GWAS) for tick resistance in cattle resulting in 1353 candidate genes for post-GWAS analyses. From those, genes showing possible structural variants from the bovine genome were classified by the Variant Effect Predictor from Ensembl. Ninety-two candidate genes showed potential structural variants in 5' UTR and coding region and were used for functional annotation. Enriched biological processes (e.g. regulation of eosinophil chemotaxis, RIG-I signalling pathway and monocyte differentiation) and candidate genes (e.g. DAPK2, PUM1, ACIN1, INPP5D) linked with immune system function were identified and thus associated with tick resistance. Besides, gene-transcription factors (TFs) networks were obtained from TFs associated with immune system (FOXO3, PPARG, STAT3, NFKB1, GATA3 and ARNT) and the candidate genes associated with tick resistance in cattle highlighted (e.g. OR4L1, PNP, LRRIQ1, GIMAP8, MYO6, MEP1A and LRFN2). Thus, promising candidate genes with a possible functional role for tick resistance in cattle are presented for further in vitro and/or in vivo analyses.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectEctoparasita
dc.subjectSistema imunológico
dc.titleCandidate genes for tick resistance in cattle: a systematic review combining post-GWAS analyses with sequencing data.
dc.typeArtigo de periódico
dc.subject.thesagroBovino
dc.subject.thesagroCarrapato
dc.subject.thesagroGenoma
dc.subject.thesagroCarne
dc.subject.thesagroHospedeiro Animal
riaa.ainfo.id1144893
riaa.ainfo.lastupdate2022-07-25
dc.identifier.doihttps://doi.org/10.1080/09712119.2022.2096035
dc.contributor.institutionCASSIANE GOMES DOS SANTOS, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionMARIELE FREITAS SOUSA, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionJOÃO INÁCIO GOMES VIEIRA, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionLUANA RAFAELA DE MORAIS, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionALINE AUXILIADORA SILVA FERNANDES, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionTHAYSSA DE OLIVEIRA LITTIERE, Universidade Estadual Paulista "Júlio de Mesquita Filho"eng
dc.contributor.institutionPAMELA ITAJARA OTTO, Universidade Federal de Santa Mariaeng
dc.contributor.institutionMARCO ANTONIO MACHADO, CNPGLeng
dc.contributor.institutionMARCOS VINICIUS GUALBERTO B SILVA, CNPGLeng
dc.contributor.institutionCRISTINA MOREIRA BONAFÉ, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionANA FABRÍCIA BRAGA MAGALHÃES, Universidade Federal dos Vales do Jequitinhonha e Mucurieng
dc.contributor.institutionLUCAS LIMA VERARDO, Universidade Federal dos Vales do Jequitinhonha e Mucuri.eng
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