Please use this identifier to cite or link to this item: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1145818
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dc.contributor.authorPAIXÃO, R. V.
dc.contributor.authorSILVA, G. F. da
dc.contributor.authorCAETANO, A. R.
dc.contributor.authorCINTRA, L. C.
dc.contributor.authorVARELA, E. S.
dc.contributor.authorO'SULLIVAN, F. L. A.
dc.date.accessioned2022-08-29T12:19:41Z-
dc.date.available2022-08-29T12:19:41Z-
dc.date.created2022-08-29
dc.date.issued2022
dc.identifier.citationGene, v. 843, art. 146795, Nov. 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1145818-
dc.descriptionThe genes coding for Cytochrome P450 aromatase (cyp19a1a and cyp19a1b) and estrogen (E2) receptors (esr1, esr2a and esr2b) play a conserved role in ovarian differentiation and development among teleosts. Classically, the "gonad form" of aromatase, coded by the cyp19a1a, is responsible for the ovarian differentiation in genetic females via ligation and activation of the Esr, which mediates the endocrine and exocrine signaling to allow or block the establishment of the feminine phenotype. However, in neotropical species, studies on the molecular and endocrine processes involved in gonad differentiation as well as on the effects of sex modulators are recent and scarce. In this study, we combined in silico analysis, real-time quantitative PCR (qPCR) assay and quantification of E2 plasma levels of differentiating tambaqui (Colossoma macropomum) to unveil the roles of the paralogs cypa19a1a and cyp19a1b during sex differentiation.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectSynteny
dc.subjectPromoter Structure
dc.subjectSex development
dc.subjectNeotropical fish
dc.titlePhylogenomic and expression analysis of Colossoma macropomum cyp19a1a and cyp19a1b and their non-classical role in tambaqui sex differentiation.
dc.typeArtigo de periódico
dc.subject.thesagroTambaqui
dc.subject.thesagroColossoma Macropomum
dc.subject.nalthesaurusAromatase
riaa.ainfo.id1145818
riaa.ainfo.lastupdate2022-08-29
dc.identifier.doihttps://doi.org/10.1016/j.gene.2022.146795
dc.contributor.institutionR. V. PAIXÃO, UNIVERSIDADE FEDERAL DO AMAZONAS; GILVAN FERREIRA DA SILVA, CPAA; ALEXANDRE RODRIGUES CAETANO, Cenargen; LEANDRO CARRIJO CINTRA, CNPTIA; EDUARDO SOUSA VARELA, CNPASA; FERNANDA LOUREIRO ALMEIDA OSULLIVAN, CPAA.
Appears in Collections:Artigo em periódico indexado (CPAA)

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