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dc.contributor.authorFANALLI, S. L.
dc.contributor.authorSILVA, B. P. M. DA
dc.contributor.authorGOMES, J. D.
dc.contributor.authorCICONELLO, F. N.
dc.contributor.authorALMEIDA, V. V. DE
dc.contributor.authorFREITAS, F. A. O.
dc.contributor.authorMOREIRA, G. C. M.
dc.contributor.authorVIGNATO, B. S.
dc.contributor.authorAFONSO, J.
dc.contributor.authorREECY, J.
dc.contributor.authorKOLTES, J.
dc.contributor.authorKOLTES, D.
dc.contributor.authorREGITANO, L. C. de A.
dc.contributor.authorBAILEIRO, J. C. DE C.
dc.contributor.authorFREITAS, L.
dc.contributor.authorCOUTINHO, L. L.
dc.contributor.authorFUKUMASU, H.
dc.contributor.authorALENCAR, S. M. DE
dc.contributor.authorLUCHIARI FILHO, A.
dc.contributor.authorCESAR, A. S. M.
dc.date.accessioned2022-09-01T12:19:51Z-
dc.date.available2022-09-01T12:19:51Z-
dc.date.created2022-09-01
dc.date.issued2022
dc.identifier.citationScientific Reports, v. 12, 10318, jun. 2022.
dc.identifier.urihttp://www.alice.cnptia.embrapa.br/alice/handle/doc/1145965-
dc.descriptionDietary fatty acids (FA) are components of the lipids, which contribute to membrane structure, energy input, and biological functions related to cellular signaling and transcriptome regulation. However, the consumers still associate dietary FA with fat deposition and increased occurrence of metabolic diseases such as obesity and atherosclerosis. Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. The key TF were identified by functional enrichment analysis from the list of differentially expressed genes identified in liver samples between 35 pigs fed with 1.5% or 3.0% soybean oil. The functional enrichment analysis detected TF linked to lipid homeostasis and inflammatory response, such as RXRA, EGFR, and SREBP2 precursor. These findings demonstrated that key TF related to lipid metabolism could be modulated by dietary inclusion of soybean oil. It could contribute to nutrigenomics research field that aims to elucidate dietary interventions in animal and human health, as well as to drive food technology and science.
dc.language.isoeng
dc.rightsopenAccess
dc.subjectLipid homeostasis
dc.subjectTranscriptome profile of animal models
dc.subjectHuman metabolic diseases
dc.subjectDietary interventions
dc.subjectDietary fatty acids
dc.subjectDietary FA on metabolic diseases
dc.titleEffect of dietary soybean oil inclusion on liver-related transcription factors in a pig model for metabolic diseases.
dc.typeArtigo de periódico
dc.subject.nalthesaurusNutrigenomics
dc.subject.nalthesaurusLipid metabolism
dc.format.extent210 p.
riaa.ainfo.id1145965
riaa.ainfo.lastupdate2022-09-01
dc.identifier.doihttps://doi.org/10.1038/s41598-022-14069-1
dc.contributor.institutionSIMARA LARISSA FANALLI, University of São Paulo
dc.contributor.institutionBRUNA PEREIRA MARTINS DA SILVA, University of São Pauloeng
dc.contributor.institutionJULIA DEZEN GOMES, University of São Pauloeng
dc.contributor.institutionFERNANDA NERY CICONELLO, University of São Pauloeng
dc.contributor.institutionVIVIAN VEZZONI DE ALMEIDA, Federal University of Goiáseng
dc.contributor.institutionFELIPE ANDRÉ OLIVEIRA FREITAS, University of São Pauloeng
dc.contributor.institutionGABRIEL COSTA MONTEIRO MOREIRA, University of Liègeeng
dc.contributor.institutionBÁRBARA SILVA-VIGNATO, University of São Pauloeng
dc.contributor.institutionJULIANA AFONSO, University Federal of São Carloseng
dc.contributor.institutionJAMES REECY, Iowa State Universityeng
dc.contributor.institutionJAMES KOLTES, Iowa State Universityeng
dc.contributor.institutionDAWN KOLTES, Iowa State Universityeng
dc.contributor.institutionLUCIANA CORREIA DE ALMEIDA REGITANO, CPPSEeng
dc.contributor.institutionJÚLIO CESAR DE CARVALHO BAILEIRO, University of São Pauloeng
dc.contributor.institutionLUCIANA FREITAS, DB Genética de Suínoseng
dc.contributor.institutionLUIZ LEHMANN COUTINHO, University of São Pauloeng
dc.contributor.institutionHEIDGE FUKUMASU, University of São Pauloeng
dc.contributor.institutionSEVERINO MATIAS DE ALENCAR, University of São Pauloeng
dc.contributor.institutionALBINO LUCHIARI FILHO, University of São Pauloeng
dc.contributor.institutionALINE SILVA MELLO CESAR, University of São Paulo.eng
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